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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
Aug 1998 Volume 13 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Aug 1998 Volume 13 Issue 2

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Article

Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.

  • Authors:
    • H Yamamoto
    • T Monden
    • H Miyoshi
    • H Izawa
    • K Ikeda
    • M Tsujie
    • T Ohnishi
    • M Sekimoto
    • N Tomita
    • M Monden
  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Osaka University Medical School, Suita, Osaka 565, Japan.
  • Pages: 233-242
    |
    Published online on: August 1, 1998
       https://doi.org/10.3892/ijo.13.2.233
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Abstract

Cyclin dependent kinases propel the cell cycle in collaboration with cyclins. We have examined the expression of cdk2/cdc2 in adenoma and focal carcinoma in adenomatous tissue to explore their role in tumorigenesis of colorectum. Immunohistochemical study revealed that cdk2/cdc2 was overexpressed in a subsets of adenoma (14/50; 28.0%) but this overexpression was much more obvious in focal carcinoma (13/15; 86.7%). These results suggest that cdk2/cdc2 is remarkably upregulated together with a malignant change. In an effort to demonstrate a significant role for cdk2/cdc2 in colon cancer, we investigated growth and apoptosis with butyrolactone I, a specific inhibitor for cdk2/cdc2, using 4 colon carcinoma cell lines (HCT116, LoVo, HT29, Colo 320DM). Butyrolactone I inhibited proliferation of all colon carcinoma cell lines at 100 microM and it induced apoptosis in LoVo cell line with induction of p53. Our findings suggest that inhibition of cdk2/cdc2 may be a useful strategy against colon cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto H, Monden T, Miyoshi H, Izawa H, Ikeda K, Tsujie M, Ohnishi T, Sekimoto M, Tomita N, Monden M, Monden M, et al: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.. Int J Oncol 13: 233-242, 1998.
APA
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M. ... Monden, M. (1998). Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.. International Journal of Oncology, 13, 233-242. https://doi.org/10.3892/ijo.13.2.233
MLA
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M., Ohnishi, T., Sekimoto, M., Tomita, N., Monden, M."Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.". International Journal of Oncology 13.2 (1998): 233-242.
Chicago
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M., Ohnishi, T., Sekimoto, M., Tomita, N., Monden, M."Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.". International Journal of Oncology 13, no. 2 (1998): 233-242. https://doi.org/10.3892/ijo.13.2.233
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto H, Monden T, Miyoshi H, Izawa H, Ikeda K, Tsujie M, Ohnishi T, Sekimoto M, Tomita N, Monden M, Monden M, et al: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.. Int J Oncol 13: 233-242, 1998.
APA
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M. ... Monden, M. (1998). Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.. International Journal of Oncology, 13, 233-242. https://doi.org/10.3892/ijo.13.2.233
MLA
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M., Ohnishi, T., Sekimoto, M., Tomita, N., Monden, M."Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.". International Journal of Oncology 13.2 (1998): 233-242.
Chicago
Yamamoto, H., Monden, T., Miyoshi, H., Izawa, H., Ikeda, K., Tsujie, M., Ohnishi, T., Sekimoto, M., Tomita, N., Monden, M."Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.". International Journal of Oncology 13, no. 2 (1998): 233-242. https://doi.org/10.3892/ijo.13.2.233
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