Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.

  • Authors:
    • T Ueno
    • O Hashimoto
    • H Sugawara
    • R Ogata
    • N Kusaba
    • T Torimura
    • M Sata
    • K Tanikawa
  • View Affiliations

  • Published online on: August 1, 1998     https://doi.org/10.3892/ijo.13.2.297
  • Pages: 297-600
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Carboxy-terminal telopeptide of type I collagen (ICTP) is a degradation product of type I collagen. In this study, we investigated the usefulness of measuring the serum ICTP concentration for diagnosing and monitoring bone metastasis from hepatocellular carcinoma (HCC). The serum concentrations of ICTP, type I procollagen carboxy-terminal propeptide (PICP), type III procollagen aminoterminal propeptide (PIIIP), type IV collagen (Ty IV), type IV collagen 7S-domain (7S), and hyaluronic acid (HA) were measured in patients with liver cirrhosis, HCC with or HCC without bone metastasis, and in healthy controls. The diagnostic efficiency of the serum ICTP and fibrosis marker levels in the HCC patients with and without bone metastasis was evaluated using receiver operating characteristic curves. We also retrospectively examined the changes in the serum ICTP levels before and after bone metastasis in the HCC patients. The serum ICTP level was significantly higher in the HCC patients with bone metastasis than in the patients with other diseases and the healthy controls. The serum PICP, PIIIP, Ty IV, 7S and HA levels of the HCC patients with bone metastasis did not differ significantly from those of the patients without bone metastasis. The diagnostic efficiency for HCC with bone metastasis was 87% for ICTP, 51% for PICP, 65% for Ty IV, 55% for PIIIP and 51% for HA. During the follow-up, the changes in the serum ICTP values paralleled the behavior of bone metastasis. These results indicate that the measurement of serum ICTP concentration is useful for detecting and monitoring HCC patients with bone metastasis.

Related Articles

Journal Cover

Aug 1998
Volume 13 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ueno T, Hashimoto O, Sugawara H, Ogata R, Kusaba N, Torimura T, Sata M and Tanikawa K: Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.. Int J Oncol 13: 297-600, 1998.
APA
Ueno, T., Hashimoto, O., Sugawara, H., Ogata, R., Kusaba, N., Torimura, T. ... Tanikawa, K. (1998). Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.. International Journal of Oncology, 13, 297-600. https://doi.org/10.3892/ijo.13.2.297
MLA
Ueno, T., Hashimoto, O., Sugawara, H., Ogata, R., Kusaba, N., Torimura, T., Sata, M., Tanikawa, K."Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.". International Journal of Oncology 13.2 (1998): 297-600.
Chicago
Ueno, T., Hashimoto, O., Sugawara, H., Ogata, R., Kusaba, N., Torimura, T., Sata, M., Tanikawa, K."Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.". International Journal of Oncology 13, no. 2 (1998): 297-600. https://doi.org/10.3892/ijo.13.2.297