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Meso-tetraphenylporphyrin: photosensitizing properties and cytotoxic effects on cultured tumor cells.

  • Authors:
    • M Canete
    • A Villanueva
    • V Dominguez
    • S Polo
    • A Juarranz
    • J C Stockert

  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/ijo.13.3.497
  • Pages: 497-1001
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Abstract

In this study we analyzed photosensitizing and photodamaging properties of the hydrophobic meso-tetraphenylporphyrin (TPP, incorporated into liposomes) on HeLa cells. Under the fluorescence microscope, red fluorescence by TPP was detected on the cell surface. TPP followed by violet-blue or red irradiation led to cell death, blebs and plasma membrane deformations appearing immediately after photodynamic treatment. Production of singlet oxygen by TPP was studied by analyzing tryptophan photodegradation, which increased in the presence of D2O and was abolished by NaN3. Present results suggest that the plasma membrane is the main cellular target for TPP, which could be a valuable photosensitizing drug in studies on photodynamic therapy of cancer.

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Journal Cover

Sep 1998
Volume 13 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Canete M, Villanueva A, Dominguez V, Polo S, Juarranz A and Stockert J: Meso-tetraphenylporphyrin: photosensitizing properties and cytotoxic effects on cultured tumor cells.. Int J Oncol 13: 497-1001, 1998
APA
Canete, M., Villanueva, A., Dominguez, V., Polo, S., Juarranz, A., & Stockert, J. (1998). Meso-tetraphenylporphyrin: photosensitizing properties and cytotoxic effects on cultured tumor cells.. International Journal of Oncology, 13, 497-1001. https://doi.org/10.3892/ijo.13.3.497
MLA
Canete, M., Villanueva, A., Dominguez, V., Polo, S., Juarranz, A., Stockert, J."Meso-tetraphenylporphyrin: photosensitizing properties and cytotoxic effects on cultured tumor cells.". International Journal of Oncology 13.3 (1998): 497-1001.
Chicago
Canete, M., Villanueva, A., Dominguez, V., Polo, S., Juarranz, A., Stockert, J."Meso-tetraphenylporphyrin: photosensitizing properties and cytotoxic effects on cultured tumor cells.". International Journal of Oncology 13, no. 3 (1998): 497-1001. https://doi.org/10.3892/ijo.13.3.497