Low MIB-1 labeling index in anti-HCV positive hepatocellular carcinoma.

Watanuki,A; Ohwada,S; Fukusato,T; Kawate,S; Makita,F; Morishita,Y

doi:10.3892/ijo.13.5.1017

Nov 1998 Volume 13 Issue 5

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Nov 1998 Volume 13 Issue 5

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Article

Low MIB-1 labeling index in anti-HCV positive hepatocellular carcinoma.

Authors:
- A Watanuki
- S Ohwada
- T Fukusato
- S Kawate
- F Makita
- Y Morishita
View Affiliations / Copyright

Affiliations: Second Department of Surgery, Gunma University School of Medicine, Gunma 371-8511, Japan.
Pages: 1017-1039
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Published online on: November 1, 1998

https://doi.org/10.3892/ijo.13.5.1017
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Abstract

It has been reported that hepatitis C virus-related hepatocellular carcinoma (HCC) patients survive longer than hepatitis B virus-related patients. In this study, since HCC patients positive for anti-HCV antibody had significantly longer disease-free survival (p<0.05), we evaluated the proliferative activity of 58 resected HCCs and the status of their viral infections. Ki-67 (MIB-1) immunostaining, argyrophilic nucleolar organizer regions and c-myc gene amplification were examined as parameters of proliferation, and p53 overexpression was examined in relation to clinicopathologic features and prognosis. Thirty-nine patients with HCC (67%) were positive for anti-HCV antibody alone, five (9%) were negative for both anti-HCV and HBV antibodies, two (3%) were positive for both anti-HCV and HBV antibodies, and 12 (21%) had HBsAg alone. HCC patients with anti-HCV antibody had a lower MIB-1 labeling index (LI) than HCC patients negative for the antibody (p<0.05), irrespective of the serum HBsAg status. However, there was no significant correlation between anti-HCV antibody and other proliferative parameters. MIB-1 could simply be related to cellular proliferation. On the other hand, the other parameters may be related to tumor progression as well as proliferation. HCV-related HCC does have lower proliferative activity and a better prognosis.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Low MIB-1 labeling index in anti-HCV positive hepatocellular carcinoma.

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Abstract

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