Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.

Obermair,A; Speiser,P; Thoma,M; Kaider,A; Salzer,H; Dittrich,C; Sevelda,P

doi:10.3892/ijo.13.5.1023

Nov 1998 Volume 13 Issue 5

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Nov 1998 Volume 13 Issue 5

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Article

Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.

Authors:
- A Obermair
- P Speiser
- M Thoma
- A Kaider
- H Salzer
- C Dittrich
- P Sevelda
View Affiliations / Copyright

Affiliations: Department of Gynecology and Obstetrics, Vienna University Medical School, A-1090 Vienna, Austria.
Pages: 1023-1053
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Published online on: November 1, 1998

https://doi.org/10.3892/ijo.13.5.1023
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Abstract

We present the data from 105 patients with primary epithelial ovarian cancer, who received up to 6 cycles of carboplatin (300 mg/m2) and cisplatin (100 mg/m2) as one treatment arm of a prospective randomized trial. Values for first-course carboplatin area-under-the-curve (AUC) were determined retrospectively. WHO grade 3-4 thrombocytopenia was found in 10% of patients with low AUC (AUC <4 mg/ml x min), but in 44.6% of patients with high AUC (AUC 4 mg/ml x min) (chi-square p<0.0001). No single case of ototoxicity was found in the low AUC group but in 12% of patients in the high AUC group (chi-square p=0.003). Determination of carboplatin AUC may prevent ototoxicity and severe thrombocytopenia for the first cycle of combined treatment with carboplatin and cisplatin.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.

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Abstract

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