Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.

  • Authors:
    • A Obermair
    • P Speiser
    • M Thoma
    • A Kaider
    • H Salzer
    • C Dittrich
    • P Sevelda
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.1023
  • Pages: 1023-1053
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Abstract

We present the data from 105 patients with primary epithelial ovarian cancer, who received up to 6 cycles of carboplatin (300 mg/m2) and cisplatin (100 mg/m2) as one treatment arm of a prospective randomized trial. Values for first-course carboplatin area-under-the-curve (AUC) were determined retrospectively. WHO grade 3-4 thrombocytopenia was found in 10% of patients with low AUC (AUC <4 mg/ml x min), but in 44.6% of patients with high AUC (AUC 4 mg/ml x min) (chi-square p<0.0001). No single case of ototoxicity was found in the low AUC group but in 12% of patients in the high AUC group (chi-square p=0.003). Determination of carboplatin AUC may prevent ototoxicity and severe thrombocytopenia for the first cycle of combined treatment with carboplatin and cisplatin.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Obermair A, Speiser P, Thoma M, Kaider A, Salzer H, Dittrich C and Sevelda P: Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.. Int J Oncol 13: 1023-1053, 1998
APA
Obermair, A., Speiser, P., Thoma, M., Kaider, A., Salzer, H., Dittrich, C., & Sevelda, P. (1998). Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.. International Journal of Oncology, 13, 1023-1053. https://doi.org/10.3892/ijo.13.5.1023
MLA
Obermair, A., Speiser, P., Thoma, M., Kaider, A., Salzer, H., Dittrich, C., Sevelda, P."Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.". International Journal of Oncology 13.5 (1998): 1023-1053.
Chicago
Obermair, A., Speiser, P., Thoma, M., Kaider, A., Salzer, H., Dittrich, C., Sevelda, P."Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin.". International Journal of Oncology 13, no. 5 (1998): 1023-1053. https://doi.org/10.3892/ijo.13.5.1023