Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin.

  • Authors:
    • S Hiscox
    • W G Jiang
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.1077
  • Pages: 1077-1157
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Abstract

Protein tyrosine phosphorylation and dephosphorylation is regulated by the action of protein tyrosine kinases (PTK) and phosphatases (PTP) respectively. The receptor type phosphatase, PTPmu, is located at the cell surface where it may function to regulate the phosphoryl status of members of the cadherin adhesion complex and thus cadherin function. We have investigated the association of PTPmu with E-cadherin and catenin molecules in human tumour cells and report that PTPmu; is associated with E-cadherin and alpha and beta-catenin in E-cadherin-positive cell lines. However, no association between PTPmu and catenin members could be detected in E-cadherin negative cells. These observations suggest that the association of PTPmu with catenin molecules may occur via E-cadherin rather than a direct interaction.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hiscox S and Hiscox S: Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin.. Int J Oncol 13: 1077-1157, 1998
APA
Hiscox, S., & Hiscox, S. (1998). Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin.. International Journal of Oncology, 13, 1077-1157. https://doi.org/10.3892/ijo.13.5.1077
MLA
Hiscox, S., Jiang, W."Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin.". International Journal of Oncology 13.5 (1998): 1077-1157.
Chicago
Hiscox, S., Jiang, W."Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin.". International Journal of Oncology 13, no. 5 (1998): 1077-1157. https://doi.org/10.3892/ijo.13.5.1077