Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).

  • Authors:
    • U Reuning
    • V Magdolen
    • O Wilhelm
    • K Fischer
    • V Lutz
    • H Graeff
    • M Schmitt
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.893
  • Pages: 893-1799
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Abstract

Tumor cell migration and invasion into the surrounding tissue depend on the invasive capacity of cells leading to the loosening of cell-cell and cell-substratum contacts via cell surface associated proteolytic enzyme systems. Plasmin is one of the enzymes involved in these complex events. It is generated by the cleavage of the proenzyme plasminogen upon the action of the urokinase-type plasminogen activator (uPA). uPA is synthesized and secreted by tumor cells and normal cells and interacts with a specific cell surface receptor (uPAR) thereby focalizing enzymatic activity to the cell surface. The activity of uPA is controlled by plasminogen activator inhibitors type-1 and type-2. A strong statistically independent prognostic impact has been attributed to uPA and its inhibitor PAI-1 in a variety of malignancies. Besides its proteolytic activity, uPA in concert with uPAR exert biological effects characteristic for molecules with signal transducing properties including chemotaxis, migration/invasion, adhesion, and mitogenesis.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Reuning U, Magdolen V, Wilhelm O, Fischer K, Lutz V, Graeff H and Schmitt M: Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).. Int J Oncol 13: 893-1799, 1998
APA
Reuning, U., Magdolen, V., Wilhelm, O., Fischer, K., Lutz, V., Graeff, H., & Schmitt, M. (1998). Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).. International Journal of Oncology, 13, 893-1799. https://doi.org/10.3892/ijo.13.5.893
MLA
Reuning, U., Magdolen, V., Wilhelm, O., Fischer, K., Lutz, V., Graeff, H., Schmitt, M."Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).". International Journal of Oncology 13.5 (1998): 893-1799.
Chicago
Reuning, U., Magdolen, V., Wilhelm, O., Fischer, K., Lutz, V., Graeff, H., Schmitt, M."Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).". International Journal of Oncology 13, no. 5 (1998): 893-1799. https://doi.org/10.3892/ijo.13.5.893