Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.

Fukushima,Y; Oshika,Y; Tsuchida,T; Tokunaga,T; Hatanaka,H; Kijima,H; Yamazaki,H; Ueyama,Y; Tamaoki,N; Nakamura,M

doi:10.3892/ijo.13.5.967

Nov 1998 Volume 13 Issue 5

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Nov 1998 Volume 13 Issue 5

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Article

Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.

Authors:
- Y Fukushima
- Y Oshika
- T Tsuchida
- T Tokunaga
- H Hatanaka
- H Kijima
- H Yamazaki
- Y Ueyama
- N Tamaoki
- M Nakamura
View Affiliations / Copyright

Affiliations: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Pages: 967-1037
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Published online on: November 1, 1998

https://doi.org/10.3892/ijo.13.5.967
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Abstract

Brain-specific angiogenesis inhibitor (BAI) 1 was recently isolated as a novel p53 inducible gene. BAI1 has been suggested to play a significant role in angiostasis. We studied the expression of BAI1 in 49 colorectal cancer specimens by RT-PCR. BAI1 expression was significantly reduced in colorectal cancers as compared to the extraneoplastic tissues (X(2) test, p=0.041). BAI1 expression was inversely correlated with vascular invasion and metastasis (Fisher's exact test, p 0.045). Moreover, vascularity in the colorectal cancer was inversely correlated with BAI1 gene expression (Mann-Whitney U-test, p=0.0003). These observations suggested that BAI1 expression might inhibit angiogenesis and metastasis of colorectal cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.

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Abstract

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