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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 1998 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1998 Volume 13 Issue 6

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Article

Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.

  • Authors:
    • H Yoshida
    • H Kijima
    • Y Terasaki
    • A Suto
    • T Takeshita
    • H Omiya
    • K Shimojima
    • M Shimbori
    • T Sato
    • S Sato
    • N Onoda
    • H Yamazaki
    • N Tamaoki
    • Y Ueyama
    • M Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Yamato Municipal Hospital, Yamato, Kanagawa 242-0012, Japan.
  • Pages: 1141-1147
    |
    Published online on: December 1, 1998
       https://doi.org/10.3892/ijo.13.6.1141
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Abstract

The nm23 gene was originally identified by differential hybridization of metastatic murine melanoma cell lines. Some experimental studies demonstrated a significantly low metastatic potential of melanoma cell lines transfected with the nm23 gene. In this study, we clarified the relationship between intracellular nm23-immunoreactivity and lymph nodal status of human breast cancer. We analyzed 82 surgically removed breast tumors including 67 invasive carcinomas (ductal, lobular and mucinous carcinomas). The nm23 expression was diffusely positive in the benign tumors and non-invasive carcinomas. Of the invasive ductal carcinomas, lymph node metastasis was found in 67.7% (21/31) of the focally positive/negative cases and in 18.2% (4/22) of the diffusely positive cases (p<0.001). Immunohistochemically, advanced margins of invasive carcinomas with lymph node metastasis were shown to be negative for nm23 expression, while intraductal carcinoma components were positive. This observation suggested that focally positive/negative nm23 expression can be a predictor of lymph node metastasis of invasive ductal breast carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida H, Kijima H, Terasaki Y, Suto A, Takeshita T, Omiya H, Shimojima K, Shimbori M, Sato T, Sato S, Sato S, et al: Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.. Int J Oncol 13: 1141-1147, 1998.
APA
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H. ... Nakamura, M. (1998). Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.. International Journal of Oncology, 13, 1141-1147. https://doi.org/10.3892/ijo.13.6.1141
MLA
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H., Shimojima, K., Shimbori, M., Sato, T., Sato, S., Onoda, N., Yamazaki, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.". International Journal of Oncology 13.6 (1998): 1141-1147.
Chicago
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H., Shimojima, K., Shimbori, M., Sato, T., Sato, S., Onoda, N., Yamazaki, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.". International Journal of Oncology 13, no. 6 (1998): 1141-1147. https://doi.org/10.3892/ijo.13.6.1141
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida H, Kijima H, Terasaki Y, Suto A, Takeshita T, Omiya H, Shimojima K, Shimbori M, Sato T, Sato S, Sato S, et al: Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.. Int J Oncol 13: 1141-1147, 1998.
APA
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H. ... Nakamura, M. (1998). Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.. International Journal of Oncology, 13, 1141-1147. https://doi.org/10.3892/ijo.13.6.1141
MLA
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H., Shimojima, K., Shimbori, M., Sato, T., Sato, S., Onoda, N., Yamazaki, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.". International Journal of Oncology 13.6 (1998): 1141-1147.
Chicago
Yoshida, H., Kijima, H., Terasaki, Y., Suto, A., Takeshita, T., Omiya, H., Shimojima, K., Shimbori, M., Sato, T., Sato, S., Onoda, N., Yamazaki, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Heterogeneous expression of nm23 gene product as a predictor of lymph nodal status in human breast cancer.". International Journal of Oncology 13, no. 6 (1998): 1141-1147. https://doi.org/10.3892/ijo.13.6.1141
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