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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 1998 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1998 Volume 13 Issue 6

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Article

Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.

  • Authors:
    • H Matsubara
    • Y Koide
    • M Sugaya
    • Y Gunji
    • T Asano
    • T Ochiai
    • K Takegana
    • S Sakiyama
    • M Tagawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery (II) School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
  • Pages: 1217-1239
    |
    Published online on: December 1, 1998
       https://doi.org/10.3892/ijo.13.6.1217
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Abstract

We examined whether antitumor effect could be produced by retrovirally expressed human interleukin-2 (hIL-2) gene in human esophageal cancer cells (T.Tn) using immunocompromised nude mice. Loss of tumorigenicity of hIL-2-producing T.Tn (T.Tn/hIL-2) cells inoculated subcutaneously was observed in contrast to continuous tumor growth of wild-type cells, although in vitro proliferation of T.Tn/hIL-2 cells remained the same as that of wild-type cells. The antitumor effect was also evidenced by the injection of T.Tn/hIL-2 cells into established tumors of wild-type cells. The injection significantly retarded the subsequent growth of wild-type tumors. Histological examination of regressing T.Tn/hIL-2 cells revealed necrotic areas and infiltration of several types of inflammatory cells. Treatment of nude mice with anti-asialoGM1 antibody did not influence the IL-2-mediated tumor rejection. Vaccination of nude mice with irradiated T.Tn/hIL-2 cells whose secretion of hIL-2 in amount was comparable to that of unirradiated cells did not develop protective immunity. Taken together, the antitumor effect achieved in nude mice by the inoculation of T.Tn/hIL-2 cells is mediated by non-T non-natural killer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Matsubara H, Koide Y, Sugaya M, Gunji Y, Asano T, Ochiai T, Takegana K, Sakiyama S and Tagawa M: Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.. Int J Oncol 13: 1217-1239, 1998.
APA
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T. ... Tagawa, M. (1998). Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.. International Journal of Oncology, 13, 1217-1239. https://doi.org/10.3892/ijo.13.6.1217
MLA
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T., Takegana, K., Sakiyama, S., Tagawa, M."Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.". International Journal of Oncology 13.6 (1998): 1217-1239.
Chicago
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T., Takegana, K., Sakiyama, S., Tagawa, M."Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.". International Journal of Oncology 13, no. 6 (1998): 1217-1239. https://doi.org/10.3892/ijo.13.6.1217
Copy and paste a formatted citation
x
Spandidos Publications style
Matsubara H, Koide Y, Sugaya M, Gunji Y, Asano T, Ochiai T, Takegana K, Sakiyama S and Tagawa M: Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.. Int J Oncol 13: 1217-1239, 1998.
APA
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T. ... Tagawa, M. (1998). Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.. International Journal of Oncology, 13, 1217-1239. https://doi.org/10.3892/ijo.13.6.1217
MLA
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T., Takegana, K., Sakiyama, S., Tagawa, M."Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.". International Journal of Oncology 13.6 (1998): 1217-1239.
Chicago
Matsubara, H., Koide, Y., Sugaya, M., Gunji, Y., Asano, T., Ochiai, T., Takegana, K., Sakiyama, S., Tagawa, M."Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition.". International Journal of Oncology 13, no. 6 (1998): 1217-1239. https://doi.org/10.3892/ijo.13.6.1217
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