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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 1998 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1998 Volume 13 Issue 6

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Article

Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.

  • Authors:
    • N Inamdar
    • S A Kumar
    • S D Banavali
    • S Advani
    • I Magrath
    • K Bhatia
  • View Affiliations / Copyright

    Affiliations: Pediatric Oncology Branch, NCI, NIH, Bethesda, MD 20892, USA.
  • Pages: 1319-1341
    |
    Published online on: December 1, 1998
       https://doi.org/10.3892/ijo.13.6.1319
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Abstract

The TEL/AML1 translocation, which is specific for pre B-cell leukemias is predictive of a favorable treatment outcome. In contrast, translocations involving the ALL1 locus which are associated with both B and non B leukemias predict a poor outcome. To determine the relative distribution of high and low risk molecular subtypes of ALL in India, we analyzed the relative frequencies of these two translocations. The study included a random selection of 46 newly diagnosed patients of childhood ALL from the Tata Memorial Hospital, Bombay, India. Similar to the frequency observed in other world regions, we found an All1 rearrangement in less than 7% (3/46) of pre B-ALL patients. In contrast to the 25% frequency reported for other regions the low risk molecular subtype characterized by the TEL/AML1 translocation represented a comparatively smaller fraction (4/46) in this study. These results provide a preliminary support for a lower frequency of molecular subgroup of leukemias with a potential for favorable clinical outcome in precursor B-ALL from India.

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Copy and paste a formatted citation
Spandidos Publications style
Inamdar N, Kumar S, Banavali S, Advani S, Magrath I and Bhatia K: Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.. Int J Oncol 13: 1319-1341, 1998.
APA
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., & Bhatia, K. (1998). Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.. International Journal of Oncology, 13, 1319-1341. https://doi.org/10.3892/ijo.13.6.1319
MLA
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., Bhatia, K."Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.". International Journal of Oncology 13.6 (1998): 1319-1341.
Chicago
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., Bhatia, K."Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.". International Journal of Oncology 13, no. 6 (1998): 1319-1341. https://doi.org/10.3892/ijo.13.6.1319
Copy and paste a formatted citation
x
Spandidos Publications style
Inamdar N, Kumar S, Banavali S, Advani S, Magrath I and Bhatia K: Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.. Int J Oncol 13: 1319-1341, 1998.
APA
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., & Bhatia, K. (1998). Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.. International Journal of Oncology, 13, 1319-1341. https://doi.org/10.3892/ijo.13.6.1319
MLA
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., Bhatia, K."Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.". International Journal of Oncology 13.6 (1998): 1319-1341.
Chicago
Inamdar, N., Kumar, S., Banavali, S., Advani, S., Magrath, I., Bhatia, K."Comparative incidence of the rearrangements of TEL/AML1 and ALL1 genes in pediatric precursor B acute lymphoblastic leukemias in India.". International Journal of Oncology 13, no. 6 (1998): 1319-1341. https://doi.org/10.3892/ijo.13.6.1319
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