DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review).

  • Authors:
    • A Dipple
    • Q A Khan
    • J E Page
    • I Pontén
    • J Szeliga
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijo.14.1.103
  • Pages: 103-114
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A brief summary of recent research, primarily from the authors' laboratory, on polycyclic aromatic hydrocarbon carcinogens with respect to their DNA adduct formation, the mutational properties of these adducts and the effects of hydrocarbon dihydrodiol epoxide metabolites on the passage of cells through the cell cycle is presented. The concept of stealth properties of potent carcinogens, i.e. their ability to damage DNA without inducing a G1 arrest, is discussed. Also, mutation studies with dihydrodiol epoxide metabolites, the sequence-dependence of site-specific mutation, as well as the selectivity of hydrocarbon-DNA adduct formation are summarized.

Related Articles

Journal Cover

Jan 1999
Volume 14 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Dipple A, Khan Q, Page J, Pontén I and Szeliga J: DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review).. Int J Oncol 14: 103-114, 1999.
APA
Dipple, A., Khan, Q., Page, J., Pontén, I., & Szeliga, J. (1999). DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review).. International Journal of Oncology, 14, 103-114. https://doi.org/10.3892/ijo.14.1.103
MLA
Dipple, A., Khan, Q., Page, J., Pontén, I., Szeliga, J."DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review).". International Journal of Oncology 14.1 (1999): 103-114.
Chicago
Dipple, A., Khan, Q., Page, J., Pontén, I., Szeliga, J."DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review).". International Journal of Oncology 14, no. 1 (1999): 103-114. https://doi.org/10.3892/ijo.14.1.103