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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 1999 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 1999 Volume 14 Issue 1

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Article

Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.

  • Authors:
    • H Zhang
    • R Brandt
    • J Heim
    • B Meyhack

  • View Affiliations / Copyright

    Affiliations: Novartis Pharma AG, Oncology, Molecular Genetics, CH-4002 Basel, Switzerland.
  • Pages: 113-133
    |
    Published online on: January 1, 1999
       https://doi.org/10.3892/ijo.14.1.113
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Abstract

In an attempt to dissect the signal pathway in which Bax increases cellular responses to apoptotic stimuli and leads to the activation of the caspase cascade, we mutated FL5.12 Bax CL16 cells with a chemical mutagen. In this report we characterize two mutant clones, FL5.12 ms1 and m3. Both clones are resistant to IL-3 deprivation exhibiting no changes in mitochondrial membrane potential, annexin V and propidium iodide binding. FL5.12 ms1 is also resistant to staurosporine and anti-Fas antibody. In cell fusion experiments m3 behaves genetically dominant and ms1 is recessive. The results suggest that m3 has a mutation in a specific function upstream of Bax, while ms1 has a mutational block in the general pathway downstream of the 'Bcl-2 checkpoint'.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Brandt R, Heim J and Meyhack B: Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.. Int J Oncol 14: 113-133, 1999.
APA
Zhang, H., Brandt, R., Heim, J., & Meyhack, B. (1999). Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.. International Journal of Oncology, 14, 113-133. https://doi.org/10.3892/ijo.14.1.113
MLA
Zhang, H., Brandt, R., Heim, J., Meyhack, B."Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.". International Journal of Oncology 14.1 (1999): 113-133.
Chicago
Zhang, H., Brandt, R., Heim, J., Meyhack, B."Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.". International Journal of Oncology 14, no. 1 (1999): 113-133. https://doi.org/10.3892/ijo.14.1.113
Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Brandt R, Heim J and Meyhack B: Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.. Int J Oncol 14: 113-133, 1999.
APA
Zhang, H., Brandt, R., Heim, J., & Meyhack, B. (1999). Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.. International Journal of Oncology, 14, 113-133. https://doi.org/10.3892/ijo.14.1.113
MLA
Zhang, H., Brandt, R., Heim, J., Meyhack, B."Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.". International Journal of Oncology 14.1 (1999): 113-133.
Chicago
Zhang, H., Brandt, R., Heim, J., Meyhack, B."Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.". International Journal of Oncology 14, no. 1 (1999): 113-133. https://doi.org/10.3892/ijo.14.1.113
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