Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.

  • Authors:
    • S Kawate
    • S Takenoshita
    • S Ohwada
    • A Mogi
    • T Fukusato
    • F Makita
    • H Kuwano
    • Y Morishita
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijo.14.1.127
  • Pages: 127-158
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Abstract

Mutations in the transforming growth factor beta type II receptor (TGFbetaRII), Smad2, and Smad4 genes have been detected in several human cancers. However, there are no reports of mutation analysis of the entire coding regions in these genes in hepatocellular carcinoma, and the roles of these genes in hepatocarcinogenesis remain unknown. We screened 30 hepatocellular carcinomas for mutations of these genes using polymerase chain reaction single-strand conformation polymorphism. We detected no mutations, but did find 3 cases of loss of heterozygosity of chromosome 17p13.1. These results suggest that mutations of the TGFbetaRII, Smad2, and Smad4 genes are rare, and that genetic instability is uncommon in human hepatocellular carcinoma.

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Jan 1999
Volume 14 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kawate S, Takenoshita S, Ohwada S, Mogi A, Fukusato T, Makita F, Kuwano H and Morishita Y: Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.. Int J Oncol 14: 127-158, 1999
APA
Kawate, S., Takenoshita, S., Ohwada, S., Mogi, A., Fukusato, T., Makita, F. ... Morishita, Y. (1999). Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.. International Journal of Oncology, 14, 127-158. https://doi.org/10.3892/ijo.14.1.127
MLA
Kawate, S., Takenoshita, S., Ohwada, S., Mogi, A., Fukusato, T., Makita, F., Kuwano, H., Morishita, Y."Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.". International Journal of Oncology 14.1 (1999): 127-158.
Chicago
Kawate, S., Takenoshita, S., Ohwada, S., Mogi, A., Fukusato, T., Makita, F., Kuwano, H., Morishita, Y."Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.". International Journal of Oncology 14, no. 1 (1999): 127-158. https://doi.org/10.3892/ijo.14.1.127