Apoptosis and Bbcl-2 expression in gastric carcinomas: correlation withclinicopathological variables, p53 expression, cell proliferation and prognosis.

  • Authors:
    • K Aizawa
    • K Ueki
    • S Suzuki
    • H Yabusaki
    • T Kanda
    • T Nishimaki
    • T Suzuki
    • K Hatakeyama
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijo.14.1.85
  • Pages:85-176
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Abstract

We investigated apoptosis and Bcl-2 expression in 221 advanced gastric carcinomas in correlation with clinicopathological variables, p53 expression, cell proliferation and prognosis, using the in situ DNA nick end labeling method and immunohistochemistry. Apoptosis was associated with high immunoreactivity of proliferating cell nuclear antigen. Bcl-2 expression correlated with a low apoptotic index and less malignant behavior of tumors. Prognostically, Bcl-2 expression was associated with a better prognosis, whereas p53 expression was the most important prognostic risk factor. Thus, apoptosis in gastric carcinomas is associated with cell proliferation, and Bcl-2 expression may have a prognostic importance as well as p53 expression.

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January 1999
Volume 14 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Aizawa, K., Ueki, K., Suzuki, S., Yabusaki, H., Kanda, T., Nishimaki, T. ... Hatakeyama, K. (1999). Apoptosis and Bbcl-2 expression in gastric carcinomas: correlation withclinicopathological variables, p53 expression, cell proliferation and prognosis.. International Journal of Oncology, 14, 85-176. https://doi.org/10.3892/ijo.14.1.85
MLA
Aizawa, K., Ueki, K., Suzuki, S., Yabusaki, H., Kanda, T., Nishimaki, T., Suzuki, T., Hatakeyama, K."Apoptosis and Bbcl-2 expression in gastric carcinomas: correlation withclinicopathological variables, p53 expression, cell proliferation and prognosis.". International Journal of Oncology 14.1 (1999): 85-176.
Chicago
Aizawa, K., Ueki, K., Suzuki, S., Yabusaki, H., Kanda, T., Nishimaki, T., Suzuki, T., Hatakeyama, K."Apoptosis and Bbcl-2 expression in gastric carcinomas: correlation withclinicopathological variables, p53 expression, cell proliferation and prognosis.". International Journal of Oncology 14, no. 1 (1999): 85-176. https://doi.org/10.3892/ijo.14.1.85