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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Feb 1999 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1999 Volume 14 Issue 2

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Article

Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.

  • Authors:
    • M Serra
    • D Maurici
    • K Scotlandi
    • G Barbanti-Brodano
    • M C Manara
    • S Benini
    • P Picci
    • F Bertoni
    • G Bacci
    • S Sottili
    • N Baldini
  • View Affiliations / Copyright

    Affiliations: Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy.
  • Pages: 301-308
    |
    Published online on: February 1, 1999
       https://doi.org/10.3892/ijo.14.2.301
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Abstract

The transcription of MDR1 gene may be increased by mutation or loss of function of p53 gene. In this study, we investigated whether in osteosarcoma, the p53 status is correlated with overexpression of the MDR1 gene product P-glycoprotein. The relationship between P-glycoprotein expression and p53 status was analyzed by immunohistochemistry in 64 primary and 11 metastatic high-grade osteosarcomas. In the same series, we also assessed the nuclear accumulation of MDM2 protein, whose binding to p53 protein provides an alternative mechanism of p53 inactivation. No association was found between mutant-p53 and MDM2 nuclear accumulation either with P-glycoprotein expression or with clinical course. Only increased expression of P-glycoprotein in tumor cells was significantly associated with a poor outcome, further supporting the adverse prognostic value of this marker in osteosarcoma.

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Copy and paste a formatted citation
Spandidos Publications style
Serra M, Maurici D, Scotlandi K, Barbanti-Brodano G, Manara M, Benini S, Picci P, Bertoni F, Bacci G, Sottili S, Sottili S, et al: Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.. Int J Oncol 14: 301-308, 1999.
APA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S. ... Baldini, N. (1999). Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.. International Journal of Oncology, 14, 301-308. https://doi.org/10.3892/ijo.14.2.301
MLA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14.2 (1999): 301-308.
Chicago
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14, no. 2 (1999): 301-308. https://doi.org/10.3892/ijo.14.2.301
Copy and paste a formatted citation
x
Spandidos Publications style
Serra M, Maurici D, Scotlandi K, Barbanti-Brodano G, Manara M, Benini S, Picci P, Bertoni F, Bacci G, Sottili S, Sottili S, et al: Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.. Int J Oncol 14: 301-308, 1999.
APA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S. ... Baldini, N. (1999). Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.. International Journal of Oncology, 14, 301-308. https://doi.org/10.3892/ijo.14.2.301
MLA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14.2 (1999): 301-308.
Chicago
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14, no. 2 (1999): 301-308. https://doi.org/10.3892/ijo.14.2.301
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