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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 1999 Volume 14 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 1999 Volume 14 Issue 3

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Article

Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.

  • Authors:
    • E De Angelis
    • M Grassi
    • W J Gullick
    • G R Johnson
    • G B Rossi
    • A Tempesta
    • F De Angelis
    • A De Luca
    • D S Salomon
    • N Normanno

  • View Affiliations / Copyright

    Affiliations: Servizio di Oncologia Sperimentale D, ITN-Fondazione Pascale, 80131 Napoli, Italy.
  • Pages: 437-477
    |
    Published online on: March 1, 1999
       https://doi.org/10.3892/ijo.14.3.437
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Abstract

We assessed the expression of the epidermal growth factor (EGF)-related peptides, cripto-I (CR-I) and amphiregulin (AR), in a small panel of human colon adenomas and carcinomas. CR-I immunoreactivity was found in 17/31 (55%) of colon adenomas, and in 33/39 (84%) colon carcinomas. AR immunostaining was observed in 16/26 adenomas (61%) and in 20/26 carcinomas (77%). CR-I and AR staining were also assessed in 29 specimens from 24 individuals that belong to families with high incidence of colorectal carcinoma, and in 5 non-high risk individuals. Expression of CR-I was detected in 18/29 (62%) of high risk colon mucosa specimens, but only in 1/5 (20%) specimens from non-high risk individuals, while AR staining was found in 20/29 (69%) and in 4/5 (80%) of colon mucosa samples from high and low risk individuals, respectively. A majority (21/29; 72%) of the specimens from the high risk individuals had a high proliferative rate, as measured by Ki-67 staining. A statistically significant correlation was found between high proliferative rate, increased expression of CR-I and reduced expression of AR in the mucosa specimens from high risk individuals, suggesting that these might represent early events in colon tumorigenesis.

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Copy and paste a formatted citation
Spandidos Publications style
De Angelis E, Grassi M, Gullick W, Johnson G, Rossi G, Tempesta A, De Angelis F, De Luca A, Salomon D, Normanno N, Normanno N, et al: Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.. Int J Oncol 14: 437-477, 1999.
APA
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A. ... Normanno, N. (1999). Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.. International Journal of Oncology, 14, 437-477. https://doi.org/10.3892/ijo.14.3.437
MLA
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A., De Angelis, F., De Luca, A., Salomon, D., Normanno, N."Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.". International Journal of Oncology 14.3 (1999): 437-477.
Chicago
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A., De Angelis, F., De Luca, A., Salomon, D., Normanno, N."Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.". International Journal of Oncology 14, no. 3 (1999): 437-477. https://doi.org/10.3892/ijo.14.3.437
Copy and paste a formatted citation
x
Spandidos Publications style
De Angelis E, Grassi M, Gullick W, Johnson G, Rossi G, Tempesta A, De Angelis F, De Luca A, Salomon D, Normanno N, Normanno N, et al: Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.. Int J Oncol 14: 437-477, 1999.
APA
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A. ... Normanno, N. (1999). Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.. International Journal of Oncology, 14, 437-477. https://doi.org/10.3892/ijo.14.3.437
MLA
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A., De Angelis, F., De Luca, A., Salomon, D., Normanno, N."Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.". International Journal of Oncology 14.3 (1999): 437-477.
Chicago
De Angelis, E., Grassi, M., Gullick, W., Johnson, G., Rossi, G., Tempesta, A., De Angelis, F., De Luca, A., Salomon, D., Normanno, N."Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families.". International Journal of Oncology 14, no. 3 (1999): 437-477. https://doi.org/10.3892/ijo.14.3.437
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