The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.

  • Authors:
    • S J Wei
    • R L Chang
    • C Q Wong
    • X X Cui
    • N Dandamudi
    • Y P Lu
    • K A Merkler
    • J M Sayer
    • A H Conney
    • D M Jerina
  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/ijo.14.3.509
  • Pages: 509-522
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Abstract

The hypothesis that the decrease in the proportion of mutations at AT base pairs in Chinese hamster V-79 cells treated with increasing doses of (+)-(R,S,S,R)-benzo[a]pyrene diol epoxide ((+)-BPDE) is due to saturation of A for adduct formation was investigated by comparing the ratio of dA to dG adducts formed at high (0.48 microM) and low (0.04 microM) doses of [3H]-labeled (+)-BPDE. The dA to dG adduct ratio was similar in both calf thymus DNA and the genomic DNA in V-79 cells, and did not change with dose. For the V-79 cells, this ratio was also unaffected by a 24-h post treatment repair incubation.

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Mar 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wei S, Chang R, Wong C, Cui X, Dandamudi N, Lu Y, Merkler K, Sayer J, Conney A, Jerina D, Jerina D, et al: The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.. Int J Oncol 14: 509-522, 1999
APA
Wei, S., Chang, R., Wong, C., Cui, X., Dandamudi, N., Lu, Y. ... Jerina, D. (1999). The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.. International Journal of Oncology, 14, 509-522. https://doi.org/10.3892/ijo.14.3.509
MLA
Wei, S., Chang, R., Wong, C., Cui, X., Dandamudi, N., Lu, Y., Merkler, K., Sayer, J., Conney, A., Jerina, D."The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.". International Journal of Oncology 14.3 (1999): 509-522.
Chicago
Wei, S., Chang, R., Wong, C., Cui, X., Dandamudi, N., Lu, Y., Merkler, K., Sayer, J., Conney, A., Jerina, D."The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.". International Journal of Oncology 14, no. 3 (1999): 509-522. https://doi.org/10.3892/ijo.14.3.509