Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients.

  • Authors:
    • O Namikawa
    • E Shimizu
    • K Sumitomo
    • S Sone
  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijo.14.4.681
  • Pages: 681-686
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Abstract

We examined by immunoblotting antibodies that bind to p16INK4A tumor suppressor gene products in the sera of patients with lung cancer. Sera from 15 to 102 patients, including 6 with adenocarcinoma, 3 with squamous cell carcinoma, 2 with large cell carcinoma and 4 with small cell carcinoma, reacted with a glutathione-S-transferase (GST) fusion protein containing whole human anti-p16INK4A, produced by Escherichia coli. However, sera from 30 normal volunteers did not react with the GST-p16INK4A fusion protein. The background such as age, gender, performance status, histology, stage, smoking history, and prior treatment was not significantly different between the patients with and without anti-GST-p16INK4A antibodies. Circulating p16INK4A tumor suppressor products were not detected in any individuals with lung cancer or in the normal controls.

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Apr 1999
Volume 14 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Namikawa O, Shimizu E, Sumitomo K and Sone S: Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients.. Int J Oncol 14: 681-686, 1999
APA
Namikawa, O., Shimizu, E., Sumitomo, K., & Sone, S. (1999). Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients.. International Journal of Oncology, 14, 681-686. https://doi.org/10.3892/ijo.14.4.681
MLA
Namikawa, O., Shimizu, E., Sumitomo, K., Sone, S."Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients.". International Journal of Oncology 14.4 (1999): 681-686.
Chicago
Namikawa, O., Shimizu, E., Sumitomo, K., Sone, S."Analysis of antibodies to p16INK4A tumor suppressor gene products in lung cancer patients.". International Journal of Oncology 14, no. 4 (1999): 681-686. https://doi.org/10.3892/ijo.14.4.681