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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Apr 1999 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Apr 1999 Volume 14 Issue 4

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Article

Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.

  • Authors:
    • H Hisatomi
    • K Nagao
    • T Kanamaru
    • H Endo
    • M Tomimatsu
    • K Hikiji

  • View Affiliations / Copyright

    Affiliations: Center for Molecular Biology and Cytogenetics, SRL, Inc., Hino, Tokyo 191-0002, Japan.
  • Pages: 727-759
    |
    Published online on: April 1, 1999
       https://doi.org/10.3892/ijo.14.4.727
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Abstract

This study investigated the relationship between the levels of human telomerase reverse transcriptase (hTERT) mRNA and that of telomerase activity in hepatocellular carcinoma (HCC). A significant correlation between hTERT mRNA expression and telomerase activity by transfecting the gene encoding hTERT into telomerase-negative human fibroblast cells has clearly been demonstrated. However, the relationship between levels of telomerase activity and that of hTERT mRNA has yet to be elucidated. In this study, the levels of hTERT mRNA were analyzed in 24 HCC patients by real-time PCR. And the intensity of telomerase activity was analyzed by fluorescence-based TRAP method. The difference of hTERT mRNA level was highly significant between tumor tissues and non-cancerous liver tissues. And there were significant correlations between the levels of hTERT mRNA and that of telomerase activity (r=0.751) in tumor tissues. We observed a strong correlation between levels of hTERT mRNA and that of telomerase activity in HCC. Our results suggest that the levels of hTERT mRNA would be useful in genetic diagnostic tests, instead of telomerase activity, to screen at-risk patients of HCC in human liver tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Hisatomi H, Nagao K, Kanamaru T, Endo H, Tomimatsu M and Hikiji K: Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.. Int J Oncol 14: 727-759, 1999.
APA
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., & Hikiji, K. (1999). Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.. International Journal of Oncology, 14, 727-759. https://doi.org/10.3892/ijo.14.4.727
MLA
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., Hikiji, K."Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.". International Journal of Oncology 14.4 (1999): 727-759.
Chicago
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., Hikiji, K."Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.". International Journal of Oncology 14, no. 4 (1999): 727-759. https://doi.org/10.3892/ijo.14.4.727
Copy and paste a formatted citation
x
Spandidos Publications style
Hisatomi H, Nagao K, Kanamaru T, Endo H, Tomimatsu M and Hikiji K: Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.. Int J Oncol 14: 727-759, 1999.
APA
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., & Hikiji, K. (1999). Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.. International Journal of Oncology, 14, 727-759. https://doi.org/10.3892/ijo.14.4.727
MLA
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., Hikiji, K."Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.". International Journal of Oncology 14.4 (1999): 727-759.
Chicago
Hisatomi, H., Nagao, K., Kanamaru, T., Endo, H., Tomimatsu, M., Hikiji, K."Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy.". International Journal of Oncology 14, no. 4 (1999): 727-759. https://doi.org/10.3892/ijo.14.4.727
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