Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.

  • Authors:
    • M J Ruiz-Hidalgo
    • C Garcés
    • J Laborda
  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijo.14.4.777
  • Pages: 777-860
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Abstract

Notch proteins participate in interactions between several cell types involved on the specification of numerous cell fates during development. We previously showed that enforced downregulation of Notch-1 expression prevented adipogenesis of 3T3-L1 cells. Since adipogenesis of 3T3-L1 cells can be induced by oncogenic ras, we studied whether this was also the case in 3T3-L1 cells with decreased levels of Notch-1 expression. We found that oncogenic ras induces transformation and not differentiation of 3T3-L1 cells with diminished levels of Notch-1. This result suggests that Notch-1 is implicated in the interpretation of signals leading to activation of p21 Ras.

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Apr 1999
Volume 14 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ruiz-Hidalgo M, Garcés C and Laborda J: Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.. Int J Oncol 14: 777-860, 1999
APA
Ruiz-Hidalgo, M., Garcés, C., & Laborda, J. (1999). Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.. International Journal of Oncology, 14, 777-860. https://doi.org/10.3892/ijo.14.4.777
MLA
Ruiz-Hidalgo, M., Garcés, C., Laborda, J."Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.". International Journal of Oncology 14.4 (1999): 777-860.
Chicago
Ruiz-Hidalgo, M., Garcés, C., Laborda, J."Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras.". International Journal of Oncology 14, no. 4 (1999): 777-860. https://doi.org/10.3892/ijo.14.4.777