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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jun 1999 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Jun 1999 Volume 14 Issue 6

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Article

Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.

  • Authors:
    • H M Sabaawy
    • S Ikehara
    • Y Adachi
    • S Quan
    • E Feldman
    • R Kancherla
    • N G Abraham
    • T Ahmed

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA.
  • Pages: 1143-1194
    |
    Published online on: June 1, 1999
       https://doi.org/10.3892/ijo.14.6.1143
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Abstract

Gene therapy has advantages in the treatment of a variety of disorders due to its selective expression within specific mammalian cells. Several reports documented the clinical effects of interferon-alpha (IFN-alpha) in management of patients with advanced colorectal carcinoma. We report for the first time, the successful transduction of human IFN-alpha gene into colon cancer cells, COLO 201 using a replication-defective retroviral vector. Retrovirus-containing supernatant from PA 317 packaging cells was used to infect colon cancer cells, COLO 201 and NIH 3T3 cells. Transient infection showed that cell proliferation and cell viability were significantly suppressed in colon cancer cells transduced with IFN-alpha gene. Moreover, IFN-alpha-transduced cells acquired less resistance to 5-FU induced apoptosis. These data demonstrate that IFN-alpha gene transfer may have a clinical application and can be combined with chemotherapy for treatment of advanced colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sabaawy H, Ikehara S, Adachi Y, Quan S, Feldman E, Kancherla R, Abraham N and Ahmed T: Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.. Int J Oncol 14: 1143-1194, 1999.
APA
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R. ... Ahmed, T. (1999). Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.. International Journal of Oncology, 14, 1143-1194. https://doi.org/10.3892/ijo.14.6.1143
MLA
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R., Abraham, N., Ahmed, T."Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.". International Journal of Oncology 14.6 (1999): 1143-1194.
Chicago
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R., Abraham, N., Ahmed, T."Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.". International Journal of Oncology 14, no. 6 (1999): 1143-1194. https://doi.org/10.3892/ijo.14.6.1143
Copy and paste a formatted citation
x
Spandidos Publications style
Sabaawy H, Ikehara S, Adachi Y, Quan S, Feldman E, Kancherla R, Abraham N and Ahmed T: Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.. Int J Oncol 14: 1143-1194, 1999.
APA
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R. ... Ahmed, T. (1999). Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.. International Journal of Oncology, 14, 1143-1194. https://doi.org/10.3892/ijo.14.6.1143
MLA
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R., Abraham, N., Ahmed, T."Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.". International Journal of Oncology 14.6 (1999): 1143-1194.
Chicago
Sabaawy, H., Ikehara, S., Adachi, Y., Quan, S., Feldman, E., Kancherla, R., Abraham, N., Ahmed, T."Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.". International Journal of Oncology 14, no. 6 (1999): 1143-1194. https://doi.org/10.3892/ijo.14.6.1143
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