Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in cervical cancer.

  • Authors:
    • J Kodama
    • M Yoshinouchi
    • N Seki
    • A Hongo
    • Y Miyagi
    • T Kudo
  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.149
  • Pages: 149-203
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Abstract

The object of this study was to clarify the association of platelet-derived endothelial cell growth factor (PD-ECGF)/thymidine phosphorylase (dThdPase), separately assessed in cancer cells and in stroma cells, with clinicopathological factors including tumor angiogenesis and prognosis in cervical cancer. The expression of PD-ECGF was evaluated by immunohistochemical staining in 92 patients with stage Ib-II cervical cancer. The microvessel count was assessed by immunostaining for factor VIII-related antigen in the most neovascularized area. Microvessel count was significantly higher in tumors with non-squamous cell carcinoma. PD-ECGF expression in cancer cells was significantly higher in tumors with pelvic node metastasis and squamous cell carcinoma. Immunopositivity for PD-ECGF in stroma cells was significantly higher in tumors with large size and deep stromal invasion. The microvessel counts in cases with positive PD-ECGF expression in stroma cells were significantly higher than those in cases with negative PD-ECGF expression in stroma cells (p=0.048). Disease-free survival and overall survival were significantly worse in patients with deep stromal invasion, parametrial involvement, vaginal involvement, lymph-vascular space involvement, pelvic lymph node metastasis and high microvessel count. A multivariate analysis using Cox's proportional hazard model showed that high microvessel count independently predicted disease-free and overall survival. The expression of PD-ECGF in stroma cells may play a crucial role in the promotion of angiogenesis and tumor angiogenesis can be used as a useful prognostic marker for cervical cancer.

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Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kodama J, Yoshinouchi M, Seki N, Hongo A, Miyagi Y and Kudo T: Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in cervical cancer.. Int J Oncol 15: 149-203, 1999
APA
Kodama, J., Yoshinouchi, M., Seki, N., Hongo, A., Miyagi, Y., & Kudo, T. (1999). Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in cervical cancer.. International Journal of Oncology, 15, 149-203. https://doi.org/10.3892/ijo.15.1.149
MLA
Kodama, J., Yoshinouchi, M., Seki, N., Hongo, A., Miyagi, Y., Kudo, T."Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in cervical cancer.". International Journal of Oncology 15.1 (1999): 149-203.
Chicago
Kodama, J., Yoshinouchi, M., Seki, N., Hongo, A., Miyagi, Y., Kudo, T."Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in cervical cancer.". International Journal of Oncology 15, no. 1 (1999): 149-203. https://doi.org/10.3892/ijo.15.1.149