Electrochemotherapy against colorectal carcinoma: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin.

  • Authors:
    • S Kuriyama
    • M Matsumoto
    • A Mitoro
    • H Tsujinoue
    • Y Toyokawa
    • T Nakatani
    • M Yamazaki
    • S Okamoto
    • H Fukui
  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijo.15.1.89
  • Pages: 89-183
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Abstract

Effectiveness of electrochemotherapy against colorectal carcinoma (CRC) was investigated in vitro using murine CRC cell lines. Electropermeabilization did not increase the sensitivity of CRC cells to 5-fluorouracil or cisplatin. Conversely, electropermeabilization markedly increased the sensitivity of CRC cells to bleomycin (BLM), resulting in 1,000-fold higher susceptibility. Subsequent analyses revealed that electropermeabilization significantly increased intracellular BLM levels of CRC cells. These results suggest that electrochemotherapy with BLM is a promising modality for the treatment of CRC, and that electrochemotherapy can be translated from the treatment of superficial tumors to the treatment of internal tumors including CRC.

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Jul 1999
Volume 15 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kuriyama S, Matsumoto M, Mitoro A, Tsujinoue H, Toyokawa Y, Nakatani T, Yamazaki M, Okamoto S and Fukui H: Electrochemotherapy against colorectal carcinoma: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin.. Int J Oncol 15: 89-183, 1999
APA
Kuriyama, S., Matsumoto, M., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T. ... Fukui, H. (1999). Electrochemotherapy against colorectal carcinoma: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin.. International Journal of Oncology, 15, 89-183. https://doi.org/10.3892/ijo.15.1.89
MLA
Kuriyama, S., Matsumoto, M., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T., Yamazaki, M., Okamoto, S., Fukui, H."Electrochemotherapy against colorectal carcinoma: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin.". International Journal of Oncology 15.1 (1999): 89-183.
Chicago
Kuriyama, S., Matsumoto, M., Mitoro, A., Tsujinoue, H., Toyokawa, Y., Nakatani, T., Yamazaki, M., Okamoto, S., Fukui, H."Electrochemotherapy against colorectal carcinoma: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin.". International Journal of Oncology 15, no. 1 (1999): 89-183. https://doi.org/10.3892/ijo.15.1.89