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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Aug 1999 Volume 15 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 1999 Volume 15 Issue 2

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Article

The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.

  • Authors:
    • T Hirano
    • M Kakihana
    • K Tsuji
    • H Shibanuma
    • T Ohira
    • N Ikeda
    • N Kawate
    • C Konaka
    • Y Ebihara
    • H Kato

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.
  • Pages: 253-261
    |
    Published online on: August 1, 1999
       https://doi.org/10.3892/ijo.15.2.253
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Abstract

Each developmental stage in the process towards bronchial squamous cell carcinoma (normal epithelium, squamous metaplasia and early stage squamous cell carcinoma including in situ carcinoma) was examined for p21/waf1 protein expression and cell proliferation using MIB1. P21/waf1 immunoreactivity was classified into four patterns: predominantly cytoplasmic staining, exclusively nuclear staining, both nuclear and cytoplasmic staining and negative. The cases with predominantly cytoplasmic staining showed suppression of cell proliferation. Most cases with either negative or exclusively nuclear staining revealed high cell proliferation. The simultaneous evaluation of p21/waf1 and cell proliferation is valuable for clinical determination of the high risk for malignant transformation.

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Copy and paste a formatted citation
Spandidos Publications style
Hirano T, Kakihana M, Tsuji K, Shibanuma H, Ohira T, Ikeda N, Kawate N, Konaka C, Ebihara Y, Kato H, Kato H, et al: The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.. Int J Oncol 15: 253-261, 1999.
APA
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N. ... Kato, H. (1999). The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.. International Journal of Oncology, 15, 253-261. https://doi.org/10.3892/ijo.15.2.253
MLA
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N., Kawate, N., Konaka, C., Ebihara, Y., Kato, H."The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.". International Journal of Oncology 15.2 (1999): 253-261.
Chicago
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N., Kawate, N., Konaka, C., Ebihara, Y., Kato, H."The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.". International Journal of Oncology 15, no. 2 (1999): 253-261. https://doi.org/10.3892/ijo.15.2.253
Copy and paste a formatted citation
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Spandidos Publications style
Hirano T, Kakihana M, Tsuji K, Shibanuma H, Ohira T, Ikeda N, Kawate N, Konaka C, Ebihara Y, Kato H, Kato H, et al: The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.. Int J Oncol 15: 253-261, 1999.
APA
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N. ... Kato, H. (1999). The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.. International Journal of Oncology, 15, 253-261. https://doi.org/10.3892/ijo.15.2.253
MLA
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N., Kawate, N., Konaka, C., Ebihara, Y., Kato, H."The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.". International Journal of Oncology 15.2 (1999): 253-261.
Chicago
Hirano, T., Kakihana, M., Tsuji, K., Shibanuma, H., Ohira, T., Ikeda, N., Kawate, N., Konaka, C., Ebihara, Y., Kato, H."The relationship between p21/waf1 expression patterns and cell proliferation during the tumorigenesis of the bronchus.". International Journal of Oncology 15, no. 2 (1999): 253-261. https://doi.org/10.3892/ijo.15.2.253
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