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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Sep 1999 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep 1999 Volume 15 Issue 3

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Article

Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.

  • Authors:
    • Y Ohtani
    • H Kijima
    • S Dowaki
    • H Kashiwagi
    • K Tobita
    • M Tsukui
    • Y Tanaka
    • T Tsuchida
    • T Tokunaga
    • H Yamazaki
    • M Nakamura
    • Y Ueyama
    • M Tanaka
    • T Tajima
    • H Makuuchi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
  • Pages: 453-460
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/ijo.15.3.453
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Abstract

Thrombospondin-1 (TSP1) is one of the extracellular matrix glycoproteins that affect cell adhesion, motility and growth. Based on its effects on tumors, TSP1 is thought to be a potential regulator of tumor growth and metastasis. In this study, we examined TSP1 expression in human gallbladder adenocarcinoma and its clinicopathological significance. TSP1 immunoreactivity was detected mainly in the cancer stroma and was observed infrequently in cancer cells. According to the TNM classification, 74.5% (29/39) of the T2 and T3 gallbladder cancers were TSP1-positive, while none (0/14) of the T1 cancers showed TSP1 expression (p<0.001). Lymph node metastasis and venous involvement were frequently found in the TSP1-positive cases (90.0% and 87.1%, respectively) of gallbladder adenocarcinoma (p<0.001). These observations suggested that TSP1 expression plays an important role in cancer cell growth and metastasis of human gallbladder adenocarcinomas, and that stromal TSP1 immunoreactivity is a good predictor of vascular involvement and lymph node metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Ohtani Y, Kijima H, Dowaki S, Kashiwagi H, Tobita K, Tsukui M, Tanaka Y, Tsuchida T, Tokunaga T, Yamazaki H, Yamazaki H, et al: Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.. Int J Oncol 15: 453-460, 1999.
APA
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M. ... Makuuchi, H. (1999). Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.. International Journal of Oncology, 15, 453-460. https://doi.org/10.3892/ijo.15.3.453
MLA
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M., Tanaka, Y., Tsuchida, T., Tokunaga, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.". International Journal of Oncology 15.3 (1999): 453-460.
Chicago
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M., Tanaka, Y., Tsuchida, T., Tokunaga, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.". International Journal of Oncology 15, no. 3 (1999): 453-460. https://doi.org/10.3892/ijo.15.3.453
Copy and paste a formatted citation
x
Spandidos Publications style
Ohtani Y, Kijima H, Dowaki S, Kashiwagi H, Tobita K, Tsukui M, Tanaka Y, Tsuchida T, Tokunaga T, Yamazaki H, Yamazaki H, et al: Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.. Int J Oncol 15: 453-460, 1999.
APA
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M. ... Makuuchi, H. (1999). Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.. International Journal of Oncology, 15, 453-460. https://doi.org/10.3892/ijo.15.3.453
MLA
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M., Tanaka, Y., Tsuchida, T., Tokunaga, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.". International Journal of Oncology 15.3 (1999): 453-460.
Chicago
Ohtani, Y., Kijima, H., Dowaki, S., Kashiwagi, H., Tobita, K., Tsukui, M., Tanaka, Y., Tsuchida, T., Tokunaga, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.". International Journal of Oncology 15, no. 3 (1999): 453-460. https://doi.org/10.3892/ijo.15.3.453
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