p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.

  • Authors:
    • H S Goh
    • J Elnatan
    • C H Low
    • D R Smith
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijo.15.3.491
  • Pages: 491-499
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Abstract

The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restricted to patients with lymphatic dissemination, patients without evident distant metastatic lesions at the time of presentation and in tumours confined to the distal colorectum. These results suggest that the utility of p53 point mutation as a specific, patient based prognostic marker may be restricted to certain classes of patients.

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Sep 1999
Volume 15 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Goh H, Elnatan J, Low C and Smith D: p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.. Int J Oncol 15: 491-499, 1999
APA
Goh, H., Elnatan, J., Low, C., & Smith, D. (1999). p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.. International Journal of Oncology, 15, 491-499. https://doi.org/10.3892/ijo.15.3.491
MLA
Goh, H., Elnatan, J., Low, C., Smith, D."p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.". International Journal of Oncology 15.3 (1999): 491-499.
Chicago
Goh, H., Elnatan, J., Low, C., Smith, D."p53 point mutation and survival in colorectal cancer patients: effect of disease dissemination and tumour location.". International Journal of Oncology 15, no. 3 (1999): 491-499. https://doi.org/10.3892/ijo.15.3.491