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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Sep 1999 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep 1999 Volume 15 Issue 3

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Article

Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.

  • Authors:
    • Y Saitoh
    • T Goto
    • V K Puduvalli
    • M Murakami
    • M Kochi
    • V A Levin
    • A P Kyritsis
    • Y Ushio

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan.
  • Pages: 499-1003
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/ijo.15.3.499
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Abstract

N-(4-hydroxyphenyl)retinamide (fenretinide) is a synthetic retinoid with anticancer properties. We investigated the effects of fenretinide on the growth of glioma cells. Four glioma cell lines (C6, 9L, Med3 and U87) were treated with fenretinide. Cell viability and independent growth was determined by MTS assay and soft agar assay, respectively. The induction of apoptosis was evaluated by microscopic examination, flow cytometric DNA content analysis, and in situ TdT methods. Fenretinide markedly reduced cell viability of all the glioma cell lines examined at a range of concentrations from 1 to 10 microM. In all cell lines examined, fenretinide also induced morphological changes consistent with apoptosis, including cellular shrinkage, chromatin condensation, and nuclear fragmentation. Flow cytometric analysis also revealed an apoptotic pattern of the DNA content, and in situ detection of apoptosis showed increased incorporation of digoxigenin-nucleotide triphosphate in fenretinide-treated glioma cells. These findings indicate that fenretinide inhibits the growth of glioma cells via the induction of apoptosis, suggesting potential clinical use of fenretinide for treatment of glioma patients.

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Copy and paste a formatted citation
Spandidos Publications style
Saitoh Y, Goto T, Puduvalli V, Murakami M, Kochi M, Levin V, Kyritsis A and Ushio Y: Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.. Int J Oncol 15: 499-1003, 1999.
APA
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V. ... Ushio, Y. (1999). Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.. International Journal of Oncology, 15, 499-1003. https://doi.org/10.3892/ijo.15.3.499
MLA
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V., Kyritsis, A., Ushio, Y."Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.". International Journal of Oncology 15.3 (1999): 499-1003.
Chicago
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V., Kyritsis, A., Ushio, Y."Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.". International Journal of Oncology 15, no. 3 (1999): 499-1003. https://doi.org/10.3892/ijo.15.3.499
Copy and paste a formatted citation
x
Spandidos Publications style
Saitoh Y, Goto T, Puduvalli V, Murakami M, Kochi M, Levin V, Kyritsis A and Ushio Y: Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.. Int J Oncol 15: 499-1003, 1999.
APA
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V. ... Ushio, Y. (1999). Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.. International Journal of Oncology, 15, 499-1003. https://doi.org/10.3892/ijo.15.3.499
MLA
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V., Kyritsis, A., Ushio, Y."Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.". International Journal of Oncology 15.3 (1999): 499-1003.
Chicago
Saitoh, Y., Goto, T., Puduvalli, V., Murakami, M., Kochi, M., Levin, V., Kyritsis, A., Ushio, Y."Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells.". International Journal of Oncology 15, no. 3 (1999): 499-1003. https://doi.org/10.3892/ijo.15.3.499
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