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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Oct 1999 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Oct 1999 Volume 15 Issue 4

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Article

Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.

  • Authors:
    • S Seetharam
    • M J Staba
    • L P Schumm
    • K Schreiber
    • H Schreiber
    • D W Kufe
    • R R Weichselbaum

  • View Affiliations / Copyright

    Affiliations: Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Pages: 769-842
    |
    Published online on: October 1, 1999
       https://doi.org/10.3892/ijo.15.4.769
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Abstract

Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) enhances local anti-tumor effects of irradiation (IR). We demonstrate that microscopic tumor growth at a distant site is suppressed following treatment of the primary tumor with adeno-murine IL-12 (Adm.IL-12). The results support a model in which the anti-angiogenic effects of IL-12 contribute to the local anti-tumor effects of radiation, while IL-12 induced immunity suppresses growth of microscopic tumors distant from the primary irradiated site. These data suggest that combining radiotherapy with IL-12 improves both local and distant tumor control compared to either treatment alone. Immunoradiotherapy may be employed in addition to or in place of current conventional therapies to increase local control and decrease distant tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
Seetharam S, Staba M, Schumm L, Schreiber K, Schreiber H, Kufe D and Weichselbaum R: Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.. Int J Oncol 15: 769-842, 1999.
APA
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., & Weichselbaum, R. (1999). Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.. International Journal of Oncology, 15, 769-842. https://doi.org/10.3892/ijo.15.4.769
MLA
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., Weichselbaum, R."Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.". International Journal of Oncology 15.4 (1999): 769-842.
Chicago
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., Weichselbaum, R."Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.". International Journal of Oncology 15, no. 4 (1999): 769-842. https://doi.org/10.3892/ijo.15.4.769
Copy and paste a formatted citation
x
Spandidos Publications style
Seetharam S, Staba M, Schumm L, Schreiber K, Schreiber H, Kufe D and Weichselbaum R: Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.. Int J Oncol 15: 769-842, 1999.
APA
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., & Weichselbaum, R. (1999). Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.. International Journal of Oncology, 15, 769-842. https://doi.org/10.3892/ijo.15.4.769
MLA
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., Weichselbaum, R."Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.". International Journal of Oncology 15.4 (1999): 769-842.
Chicago
Seetharam, S., Staba, M., Schumm, L., Schreiber, K., Schreiber, H., Kufe, D., Weichselbaum, R."Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.". International Journal of Oncology 15, no. 4 (1999): 769-842. https://doi.org/10.3892/ijo.15.4.769
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