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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Oct 1999 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Oct 1999 Volume 15 Issue 4

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Article

Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.

  • Authors:
    • J W Chiao
    • W Xu
    • Y M Yang
    • R Kancherla
    • K Seiter
    • T Ahmed
    • A Mittelman

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.
  • Pages: 835-843
    |
    Published online on: October 1, 1999
       https://doi.org/10.3892/ijo.15.4.835
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Abstract

A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the effect of NP54 on the growth of human breast cancer cells SK-Br-3 in cultures was analyzed. Exposure to NP54 caused a dose-dependent growth modulation. Approximately 40% reduction of cell density was detected at 40 pM of NP54, along with a blocking of G1 cells entering into S phase. The growth modulation was correlated with a significantly reduced expression of epidermal growth factor receptor (EGF-R) gene transcript, supporting the interpretation that the level of EGF-R expression and cell growth are related mechanisms. NP54 treatment also significantly increased cells with apoptotic morphological feature and fragmented DNA. Incubation with a monoclonal anti-NP54 antibody negated NP54 activity, confirming a regulatory activity in cell growth and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Chiao J, Xu W, Yang Y, Kancherla R, Seiter K, Ahmed T and Mittelman A: Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.. Int J Oncol 15: 835-843, 1999.
APA
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., & Mittelman, A. (1999). Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.. International Journal of Oncology, 15, 835-843. https://doi.org/10.3892/ijo.15.4.835
MLA
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., Mittelman, A."Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.". International Journal of Oncology 15.4 (1999): 835-843.
Chicago
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., Mittelman, A."Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.". International Journal of Oncology 15, no. 4 (1999): 835-843. https://doi.org/10.3892/ijo.15.4.835
Copy and paste a formatted citation
x
Spandidos Publications style
Chiao J, Xu W, Yang Y, Kancherla R, Seiter K, Ahmed T and Mittelman A: Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.. Int J Oncol 15: 835-843, 1999.
APA
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., & Mittelman, A. (1999). Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.. International Journal of Oncology, 15, 835-843. https://doi.org/10.3892/ijo.15.4.835
MLA
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., Mittelman, A."Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.". International Journal of Oncology 15.4 (1999): 835-843.
Chicago
Chiao, J., Xu, W., Yang, Y., Kancherla, R., Seiter, K., Ahmed, T., Mittelman, A."Regulation of growth and apoptosis of breast cancer cells by a 54 kDa lymphokine.". International Journal of Oncology 15, no. 4 (1999): 835-843. https://doi.org/10.3892/ijo.15.4.835
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