Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1.

Chiao,J W; Hsieh,T C; Xu,W; Sklarew,R J; Kancherla,R

doi:10.3892/ijo.15.5.1033

Nov 1999 Volume 15 Issue 5

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Nov 1999 Volume 15 Issue 5

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Article

Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1.

Authors:
- J W Chiao
- T C Hsieh
- W Xu
- R J Sklarew
- R Kancherla
View Affiliations / Copyright

Affiliations: Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Pages: 1033-1040
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Published online on: November 1, 1999

https://doi.org/10.3892/ijo.15.5.1033
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Abstract

Growth and development of some prostate epithelial cells are androgen-dependent. Non-androgenic hormones and growth factors may also influence prostate cells and the effect of interleukin 1beta (IL-1beta) has been investigated with an androgen-dependent human prostate cancer cell line LNCaP. Exposure of LNCaP cells to IL-1beta at picomole ranges resulted in a dose-dependent and progressive differentiation to neuroendocrine-like cells evidenced by dendrite formation and the development of specific neuroendocrine cell markers. Quantification by computer-based image analysis after immunostaining revealed a two-fold increase of chromogranin A in 90% of the cells and a ten-fold increase in the remaining 10%. Additionally, serotonin was developed in all the cells with the staining intensity increased by five-fold. Significant increase in cytokeratin 8 and reduction of prostate specific antigen was also noted. Proliferation was reduced in parallel to the cellular development. The IL-1beta effect was irreversible after several days of IL-1beta incubation. IL-1beta is produced constitutively and its secreted level has an inversed relation during the exponential and plateau phases of cell growth. An IL-1 autocrine regulation in the growth and differentiation of prostate cells is discussed.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1.

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Abstract

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