Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization.

  • Authors:
    • J Nagashima
    • K Okuda
    • M Tanaka
    • M Sata
    • S Aoyagi
  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijo.15.6.1117
  • Pages: 1117-1140
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Abstract

As a strategy for treating advanced hepatocellular carcinoma (HCC), cytoreductive surgery was studied comparing to transcatheter arterial chemoembolization (TACE). Patients who had curatively unresectable intrahepatic multiple HCC with the main tumor 30 mm or more in size were selected for this study. The patients were classified into two groups; i) cytoreductive surgery group (CRS group): 28 patients in whom the main tumor was resected but other cancer nodules remained in the remnant liver, ii) TACE group: 25 patients at Child A grade who underwent TACE, and in whom it was also evaluated retrospectively that the main tumor had been resectable. The cumulative 5-year survival rate was significantly higher in CRS (48.7%) than TACE (17.1%) group. Multivariate analysis revealed that performing cytoreductive surgery was a significant and independent factor to prolong survival. However, 6 of 28 patients died within one year of surgery. Residual tumor thrombus, and the absence or non-effectiveness of adjuvant therapy were significant high risk factors for postoperative death within one year. Conclusively, cytoreductive surgery contributes to a significant lengthening of survival in patients with advanced HCC. To reduce the risk of early postoperative death, the importance of postoperative adjuvant therapy is also recognized.

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Dec 1999
Volume 15 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nagashima J, Okuda K, Tanaka M, Sata M and Aoyagi S: Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization.. Int J Oncol 15: 1117-1140, 1999
APA
Nagashima, J., Okuda, K., Tanaka, M., Sata, M., & Aoyagi, S. (1999). Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization.. International Journal of Oncology, 15, 1117-1140. https://doi.org/10.3892/ijo.15.6.1117
MLA
Nagashima, J., Okuda, K., Tanaka, M., Sata, M., Aoyagi, S."Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization.". International Journal of Oncology 15.6 (1999): 1117-1140.
Chicago
Nagashima, J., Okuda, K., Tanaka, M., Sata, M., Aoyagi, S."Prognostic benefit in cytoreductive surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization.". International Journal of Oncology 15, no. 6 (1999): 1117-1140. https://doi.org/10.3892/ijo.15.6.1117