In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.

Martin-Duque,P; Sánchez-Prieto,R; Romero,J; Martinez-Lamparero,A; Cebrian-Sagarriga,S; Guinea-Viniegra,J; Dominguez,C; Lleonart,M; Cano,A; Quintanilla,M; Ramón Y Cajal,S

doi:10.3892/ijo.15.6.1163

Dec 1999 Volume 15 Issue 6

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Dec 1999 Volume 15 Issue 6

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Article

In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.

Authors:
- P Martin-Duque
- R Sánchez-Prieto
- J Romero
- A Martinez-Lamparero
- S Cebrian-Sagarriga
- J Guinea-Viniegra
- C Dominguez
- M Lleonart
- A Cano
- M Quintanilla
- S Ramón Y Cajal
View Affiliations / Copyright

Affiliations: Department of Pathology, Clinica Puerta de Hierro, Madrid, Spain.
Pages: 1163-1171
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Published online on: December 1, 1999

https://doi.org/10.3892/ijo.15.6.1163
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Abstract

The adenovirus E1A gene is a potent inducer of chemosensitivity and radiosensitivity through p53-dependent and independent mechanisms. We have studied the sensitivity of murine (MSC11A5, a sarcomatoid epidermoid carcinoma) and human (HeLa, human cervix carcinoma) E1A-expressing tumors, in vivo, after treatment with cisplatin or gamma-irradiation. In athymic mice, half-body irradiation was performed in an AECL Cobalt unit, at an SSD of 80 cm. Daily fractions of 300 cGy over 3 days, up to a total dose of 9 Gy. Cisplatin was injected intraperitoneally at a dose of 9 mg per kg of body weight. After gamma-irradiation or intraperitoneal injection of cisplatin, about 30% of the E1A-expressing tumors regressed completely or were associated with a marked decrease in tumorigenicity over the following weeks. We conclude that malignant tumors, when expressing adenovirus E1A, are very sensitive to treatment with DNA-damaging agents, in vivo, regardless of the p53 status of the tumors.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.

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