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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 1999 Volume 15 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1999 Volume 15 Issue 6

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Article

The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.

  • Authors:
    • T Sano
    • E C Gabazza
    • H Zhou
    • H Takeya
    • T Hayashi
    • M Ido
    • Y Adachi
    • A Uchida
    • K Suzuki
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathobiology, Mie University School of Medicine, Tsu-city, Mie, Japan.
  • Pages: 1197-1400
    |
    Published online on: December 1, 1999
       https://doi.org/10.3892/ijo.15.6.1197
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Abstract

The coagulation system plays a role in tumor invasion and metastasis. Prothrombin was previously found to stimulate the motility of melanoma cells. We compared the effect of prothrombin and thrombin on cell motility, calcium influx and actin stress filament contraction in highly metastatic osteosarcoma LM8 cells. Prothrombin and thrombin stimulated chemotaxis and chemokinesis of LM8 cells in a dose-dependent manner. Calcium influx was significantly increased after stimulation with thrombin and prothrombin. Thrombin and prothrombin markedly stimulated actin contraction in LM8 cells. Hirudin inhibited the effects of thrombin but not those of prothrombin. Prothrombin appears to stimulate cell locomotion, actin contraction, calcium influx in LM8 cells by different mechanism from thrombin.

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Copy and paste a formatted citation
Spandidos Publications style
Sano T, Gabazza E, Zhou H, Takeya H, Hayashi T, Ido M, Adachi Y, Uchida A and Suzuki K: The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. Int J Oncol 15: 1197-1400, 1999.
APA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M. ... Suzuki, K. (1999). The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. International Journal of Oncology, 15, 1197-1400. https://doi.org/10.3892/ijo.15.6.1197
MLA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15.6 (1999): 1197-1400.
Chicago
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15, no. 6 (1999): 1197-1400. https://doi.org/10.3892/ijo.15.6.1197
Copy and paste a formatted citation
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Spandidos Publications style
Sano T, Gabazza E, Zhou H, Takeya H, Hayashi T, Ido M, Adachi Y, Uchida A and Suzuki K: The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. Int J Oncol 15: 1197-1400, 1999.
APA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M. ... Suzuki, K. (1999). The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.. International Journal of Oncology, 15, 1197-1400. https://doi.org/10.3892/ijo.15.6.1197
MLA
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15.6 (1999): 1197-1400.
Chicago
Sano, T., Gabazza, E., Zhou, H., Takeya, H., Hayashi, T., Ido, M., Adachi, Y., Uchida, A., Suzuki, K."The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.". International Journal of Oncology 15, no. 6 (1999): 1197-1400. https://doi.org/10.3892/ijo.15.6.1197
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