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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 2000 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 2000 Volume 16 Issue 1

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Article

Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.

  • Authors:
    • N Koyama
    • J Nishihira
    • H Nakabayashi
    • S Nishi
    • N Hoshi
    • S Fujimoto
    • M Shimizu
    • T Yoshiki
    • T Sugihara

  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Hokkaido University School of Medicine, Sapporo 060-8638, Japan.
  • Pages: 15-38
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijo.16.1.15
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Abstract

Although basal cell carcinoma (BCC) is a major skin cancer, the mechanism of carcinogenesis with regard to cytogenetic abnormalities has not been fully investigated. In the present study, we carried out cytogenetic analyses of 18 patients (9 male and 9 female) with BCC. Aneuploidy was seen by Q-banding method in more than half of the cases and was mostly loss of the sex chromosome. We also performed FISH to the interphase nuclei of various tissues and short-term cultured BCC cells. The frequency of sex chromosomal aneuploidy was significantly higher in all samples from BCC patients (peripheral blood lymphocytes, non-lesional tissues, BCC tumor tissues and cultured BCC cells) than in age-matched normal controls. In addition, we analyzed clonality of BCC tissues using a human androgen receptor gene assay and found uniparental pattern of inactive X-chromosomes. This indicates that BCC cells were monoclonal in origin and the development of BCC might be correlated with sex chromosomal aneuploidy, which acquired accumulation of genetic mutations.

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Copy and paste a formatted citation
Spandidos Publications style
Koyama N, Nishihira J, Nakabayashi H, Nishi S, Hoshi N, Fujimoto S, Shimizu M, Yoshiki T and Sugihara T: Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.. Int J Oncol 16: 15-38, 2000.
APA
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S. ... Sugihara, T. (2000). Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.. International Journal of Oncology, 16, 15-38. https://doi.org/10.3892/ijo.16.1.15
MLA
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S., Shimizu, M., Yoshiki, T., Sugihara, T."Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.". International Journal of Oncology 16.1 (2000): 15-38.
Chicago
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S., Shimizu, M., Yoshiki, T., Sugihara, T."Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.". International Journal of Oncology 16, no. 1 (2000): 15-38. https://doi.org/10.3892/ijo.16.1.15
Copy and paste a formatted citation
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Spandidos Publications style
Koyama N, Nishihira J, Nakabayashi H, Nishi S, Hoshi N, Fujimoto S, Shimizu M, Yoshiki T and Sugihara T: Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.. Int J Oncol 16: 15-38, 2000.
APA
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S. ... Sugihara, T. (2000). Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.. International Journal of Oncology, 16, 15-38. https://doi.org/10.3892/ijo.16.1.15
MLA
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S., Shimizu, M., Yoshiki, T., Sugihara, T."Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.". International Journal of Oncology 16.1 (2000): 15-38.
Chicago
Koyama, N., Nishihira, J., Nakabayashi, H., Nishi, S., Hoshi, N., Fujimoto, S., Shimizu, M., Yoshiki, T., Sugihara, T."Aneuploidy of sex chromosomes in basal cell carcinoma: its clonality and involvement in the development of carcinogenesis.". International Journal of Oncology 16, no. 1 (2000): 15-38. https://doi.org/10.3892/ijo.16.1.15
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