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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 2000 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 2000 Volume 16 Issue 1

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Article

Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.

  • Authors:
    • R R Mehta
    • L Bratescu
    • J M Graves
    • A Green
    • R G Mehta

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, University of Illinois at Chicago, M/C 820, Chicago, IL 60612, USA.
  • Pages: 65-138
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijo.16.1.65
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Abstract

The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] that exhibits much less calcemic activity than 1alpha,25-dihydroxyvitamin D3. In this study, we evaluated the cell-differentiating action of 1alpha(OH)D5 in breast cancer cells. Following 10 days treatment with 1alpha(OH)D5 [(10-7 M) in UISO-BCA-4], we observed induction of intracytoplasmic casein, intracytoplasmic lipid droplets, ICAM-1, nm23, and specific biomarkers associated with breast cell differentiation. 1alpha(OH)D5 treatment also showed induction of vitamin D receptor and TGFbeta1 proteins. UISO-BCA-4 cells pretreated for 10 days in vitro with 1 microM 1alpha(OH)D5 failed to form tumors when transplanted into athymic mice. Similarly, 4 and 8 ng 1alpha(OH)D5 treatment three times weekly inhibited the growth of UISO-BCA-4 cells injected into athymic mice. These results suggest that this new vitamin D analog may be of significant therapeutic value for breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Mehta R, Bratescu L, Graves J, Green A and Mehta R: Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.. Int J Oncol 16: 65-138, 2000.
APA
Mehta, R., Bratescu, L., Graves, J., Green, A., & Mehta, R. (2000). Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.. International Journal of Oncology, 16, 65-138. https://doi.org/10.3892/ijo.16.1.65
MLA
Mehta, R., Bratescu, L., Graves, J., Green, A., Mehta, R."Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.". International Journal of Oncology 16.1 (2000): 65-138.
Chicago
Mehta, R., Bratescu, L., Graves, J., Green, A., Mehta, R."Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.". International Journal of Oncology 16, no. 1 (2000): 65-138. https://doi.org/10.3892/ijo.16.1.65
Copy and paste a formatted citation
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Spandidos Publications style
Mehta R, Bratescu L, Graves J, Green A and Mehta R: Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.. Int J Oncol 16: 65-138, 2000.
APA
Mehta, R., Bratescu, L., Graves, J., Green, A., & Mehta, R. (2000). Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.. International Journal of Oncology, 16, 65-138. https://doi.org/10.3892/ijo.16.1.65
MLA
Mehta, R., Bratescu, L., Graves, J., Green, A., Mehta, R."Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.". International Journal of Oncology 16.1 (2000): 65-138.
Chicago
Mehta, R., Bratescu, L., Graves, J., Green, A., Mehta, R."Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1alpha-hydroxyvitamin D5.". International Journal of Oncology 16, no. 1 (2000): 65-138. https://doi.org/10.3892/ijo.16.1.65
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