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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Feb 2000 Volume 16 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 2000 Volume 16 Issue 2

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Article

TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.

  • Authors:
    • T Koyama
    • M Yashiro
    • T Inoue
    • S Nishimura
    • K Hirakawa-YS Chung
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
  • Pages: 355-417
    |
    Published online on: February 1, 2000
       https://doi.org/10.3892/ijo.16.2.355
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Abstract

Gastric fibroblast-derived conditioned medium and TGF-beta1 stimulated the adhesion ability of scirrhous gastric cancer cells to mesothelial cells, but not that of well-differentiated gastric cancer cells. The CD44H expression of scirrhous gastric cancer cells was significantly up-regulated by gastric fibroblast-derived CM and TGF-beta1. The stimulated adhesion ability and CD44H expression was significantly inhibited by anti TGF-beta1 neutralizing antibody. These findings suggested that TGF-beta1 secreted by gastric fibroblasts up-regulated the CD44H expression of scirrhous gastric cancer cells, which resulted in the stimulation of the adhesion ability of scirrhous gastric cancer cells to the mesothelium, and increased the peritoneal dissemination potential. These results might explain one of the reasons why scirrhous gastric carcinomas develop frequent peritoneal dissemination.

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Copy and paste a formatted citation
Spandidos Publications style
Koyama T, Yashiro M, Inoue T, Nishimura S and Hirakawa-YS Chung K: TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.. Int J Oncol 16: 355-417, 2000.
APA
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., & Hirakawa-YS Chung, K. (2000). TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.. International Journal of Oncology, 16, 355-417. https://doi.org/10.3892/ijo.16.2.355
MLA
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., Hirakawa-YS Chung, K."TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.". International Journal of Oncology 16.2 (2000): 355-417.
Chicago
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., Hirakawa-YS Chung, K."TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.". International Journal of Oncology 16, no. 2 (2000): 355-417. https://doi.org/10.3892/ijo.16.2.355
Copy and paste a formatted citation
x
Spandidos Publications style
Koyama T, Yashiro M, Inoue T, Nishimura S and Hirakawa-YS Chung K: TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.. Int J Oncol 16: 355-417, 2000.
APA
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., & Hirakawa-YS Chung, K. (2000). TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.. International Journal of Oncology, 16, 355-417. https://doi.org/10.3892/ijo.16.2.355
MLA
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., Hirakawa-YS Chung, K."TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.". International Journal of Oncology 16.2 (2000): 355-417.
Chicago
Koyama, T., Yashiro, M., Inoue, T., Nishimura, S., Hirakawa-YS Chung, K."TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.". International Journal of Oncology 16, no. 2 (2000): 355-417. https://doi.org/10.3892/ijo.16.2.355
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