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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 2000 Volume 16 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 2000 Volume 16 Issue 3

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Article

DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.

  • Authors:
    • H Kashiwagi
    • H Kijima
    • S Dowaki
    • Y Ohtani
    • K Tobita
    • M Tsukui
    • Y Tanaka
    • H Matsubayasi
    • T Tsuchida
    • H Yamazaki
    • M Nakamura
    • Y Ueyama
    • M Tanaka
    • T Tajima
    • H Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
  • Pages: 455-464
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/ijo.16.3.455
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Abstract

DF3 (MUC 1) is a member of a family of high molecular weight glycoproteins. Recent studies have demonstrated that DF3 is expressed in tumors of various human organs, and may function as an anti-adhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis. However, expression patterns of DF3 have not yet been established in human gallbladder carcinomas. In this study, we examined DF3 expression in human gallbladder adenocarcinoma and its clinicopathological significance. DF3 immunoreactivity was detected not only in the cancer cells (cytoplasmic type; 50.0%, 27/54) but also in the cancer stroma (stromal type; 46.3%, 25/54). According to TNM classification, 65.0% (26/40) of T2-4 gallbladder cancers showed cytoplasmic DF3, while 7.1% (1/14) of the T1 cancers were cytoplasmic DF3-positive (p<0.001). Stromal DF3 expression was detected in 62.5% (25/40) and none (0/14) of the T2-4 and T1 cancers, respectively (p<0.001). Lymph node metastasis was frequently found in the cytoplasmic DF3- and stromal DF3-positive gallbladder cancers (59.3% and 60.0%, respectively). These observations suggested that DF3 expression plays important roles in cancer cell growth and metastasis of human gallbladder adenocarcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Tsukui M, Tanaka Y, Matsubayasi H, Tsuchida T, Yamazaki H, Yamazaki H, et al: DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.. Int J Oncol 16: 455-464, 2000.
APA
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M. ... Makuuchi, H. (2000). DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.. International Journal of Oncology, 16, 455-464. https://doi.org/10.3892/ijo.16.3.455
MLA
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M., Tanaka, Y., Matsubayasi, H., Tsuchida, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.". International Journal of Oncology 16.3 (2000): 455-464.
Chicago
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M., Tanaka, Y., Matsubayasi, H., Tsuchida, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.". International Journal of Oncology 16, no. 3 (2000): 455-464. https://doi.org/10.3892/ijo.16.3.455
Copy and paste a formatted citation
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Spandidos Publications style
Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Tsukui M, Tanaka Y, Matsubayasi H, Tsuchida T, Yamazaki H, Yamazaki H, et al: DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.. Int J Oncol 16: 455-464, 2000.
APA
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M. ... Makuuchi, H. (2000). DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.. International Journal of Oncology, 16, 455-464. https://doi.org/10.3892/ijo.16.3.455
MLA
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M., Tanaka, Y., Matsubayasi, H., Tsuchida, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.". International Journal of Oncology 16.3 (2000): 455-464.
Chicago
Kashiwagi, H., Kijima, H., Dowaki, S., Ohtani, Y., Tobita, K., Tsukui, M., Tanaka, Y., Matsubayasi, H., Tsuchida, T., Yamazaki, H., Nakamura, M., Ueyama, Y., Tanaka, M., Tajima, T., Makuuchi, H."DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.". International Journal of Oncology 16, no. 3 (2000): 455-464. https://doi.org/10.3892/ijo.16.3.455
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