Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.

Nordkvist,A; Röijer,E; Bang,G; Gustafsson,H; Behrendt,M; Ryd,W; Thoresen,S; Donath,K; Stenman,G

doi:10.3892/ijo.16.3.477

Mar 2000 Volume 16 Issue 3

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Mar 2000 Volume 16 Issue 3

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Article

Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.

Authors:
- A Nordkvist
- E Röijer
- G Bang
- H Gustafsson
- M Behrendt
- W Ryd
- S Thoresen
- K Donath
- G Stenman
View Affiliations / Copyright

Affiliations: Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden.
Pages: 477-560
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Published online on: March 1, 2000

https://doi.org/10.3892/ijo.16.3.477
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Abstract

The expression and mutation patterns of p53 were studied in a series of 68 benign pleomorphic adenomas and 237 malignant salivary gland tumors. p53 overexpression (nuclear staining exceeding 10%) was detected in 20% of the malignant salivary gland tumors, with the highest prevalence observed in polymorphous low grade adenocarcinoma, squamous cell carcinoma, and carcinoma ex pleomorphic adenoma and the lowest in adenoid cystic carcinoma and acinic cell carcinoma. In contrast, none of the 68 benign pleomorphic adenomas had nuclear staining exceeding 10%. SSCP and nucleotide sequence analysis of exons 4 to 9 of p53 in 19 malignant tumors revealed 9 mutations in 7 tumors. Our findings indicate that p53 may be a useful marker to help discriminate between benign and malignant salivary gland tumors.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.

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Abstract

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