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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 2000 Volume 16 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 2000 Volume 16 Issue 3

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Article

Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.

  • Authors:
    • M A Haidar
    • T Manshouri
    • M J Keating
    • H M Kantarjian
    • E J Freireich
    • K Mehta
    • M Albitar

  • View Affiliations / Copyright

    Affiliations: Department of Hematopathology, Division of Pathology, Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
  • Pages: 561-566
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/ijo.16.3.561
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Abstract

We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis in RARalpha-deficient transgenic mice, we compared the levels of RARalpha to the levels of p53 mRNA, and Bcl-2, and Bax proteins in lymphoid and non-lymphoid tissues and in lymphomas derived from the RARalpha-deficient transgenic mice. The p53 mRNA levels were depleted in various tissues including spleen ( approximately 96%), thymus ( approximately 29%) and bone marrow ( approximately 62%) of RARalpha-deficient transgenic mice when compared with the normal littermates, and the reduction in p53 mRNA expression in the various tissues examined was proportional to the reduction in RARalpha expression. Bcl-2 to Bax ratios were highly increased in the lymphoid compartments (spleen >bone marrow >thymus) because of selective overexpression of Bcl-2 protein. In summary, RARalpha downmodulation in this transgenic mouse model system was accompanied by p53 downmodulation and deregulation of Bcl-2 to Bax ratios in the lymphoid compartments.

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Copy and paste a formatted citation
Spandidos Publications style
Haidar M, Manshouri T, Keating M, Kantarjian H, Freireich E, Mehta K and Albitar M: Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.. Int J Oncol 16: 561-566, 2000.
APA
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., & Albitar, M. (2000). Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.. International Journal of Oncology, 16, 561-566. https://doi.org/10.3892/ijo.16.3.561
MLA
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., Albitar, M."Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.". International Journal of Oncology 16.3 (2000): 561-566.
Chicago
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., Albitar, M."Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.". International Journal of Oncology 16, no. 3 (2000): 561-566. https://doi.org/10.3892/ijo.16.3.561
Copy and paste a formatted citation
x
Spandidos Publications style
Haidar M, Manshouri T, Keating M, Kantarjian H, Freireich E, Mehta K and Albitar M: Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.. Int J Oncol 16: 561-566, 2000.
APA
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., & Albitar, M. (2000). Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.. International Journal of Oncology, 16, 561-566. https://doi.org/10.3892/ijo.16.3.561
MLA
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., Albitar, M."Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.". International Journal of Oncology 16.3 (2000): 561-566.
Chicago
Haidar, M., Manshouri, T., Keating, M., Kantarjian, H., Freireich, E., Mehta, K., Albitar, M."Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice.". International Journal of Oncology 16, no. 3 (2000): 561-566. https://doi.org/10.3892/ijo.16.3.561
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