Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

Jögi,A; Abel,F; Sjöberg,R M; Toftgård,R; Zaphiropoulos,P G; Påhlman,S; Martinsson,T; Axelson,H

doi:10.3892/ijo.16.5.943

May 2000 Volume 16 Issue 5

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May 2000 Volume 16 Issue 5

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Article

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

Authors:
- A Jögi
- F Abel
- R M Sjöberg
- R Toftgård
- P G Zaphiropoulos
- S Påhlman
- T Martinsson
- H Axelson
View Affiliations / Copyright

Affiliations: Department of Laboratory Medicine, Molecular Medicine, Lund University, University Hospital MAS, Malmö, Sweden.
Pages: 943-952
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Published online on: May 1, 2000

https://doi.org/10.3892/ijo.16.5.943
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Abstract

Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumor stage are loss of heterozygosity in the distal region of chromosome 1p and amplification of the N-myc gene. Patched 2 is a novel homologue to the tumor suppressor gene Patched 1, and has been mapped to 1p32-34, a part of chromosome 1 frequently deleted in high stage neuroblastoma tumors. RT-PCR analysis of 9 neuroblastoma cell lines showed expression of both Patched 1 and 2. We analyzed 14, mainly high stage, neuroblastoma tumors for mutations in the Patched 2 gene with denaturing HPLC using the Wave DNA fragment analysis system. In four tumor samples variations were detected within the coding sequence, and two of them gave rise to amino-acid substitutions. These variations were, however, also detected in normal DNA from the respective patients. We conclude that Patched 2 is expressed, but not frequently mutated, in high stage neuroblastomas and is therefore not likely to be involved in the genesis of this tumor.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

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