Detection of c-erbB-2 and FGF-3 (INT-2) gene amplification in epithelial ovarian cancer.

  • Authors:
    • A Seki
    • M Yoshinouchi
    • N Seki
    • J Kodama
    • Y Miyagi
    • T Kudo
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijo.17.1.103
  • Pages: 103-109
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We examined gene amplifications of the c-erbB-2 and FGF-3 gene in 48 epithelial ovarian cancers by differential PCR and addressed their association with clinico-pathological features including clinical outcome. Overall, 25.0 and 20.8% of ovarian cancers displayed amplified c-erbB-2 or FGF-3 gene, respectively. Amplification of the c-erbB-2 gene was significantly associated with particular histological cell types, higher histological grade, and low levels of serous CA125. However, there was no correlation between c-erbB-2 gene amplification and patient outcome. No correlation was observed between FGF-3 gene amplification and any clinico-pathological features including overall survival. These findings suggested that c-erbB-2 or FGF-3 gene amplification might be one of the oncogenic events implicated in the development of ovarian cancers, yet is not a useful prognostic marker.

Related Articles

Journal Cover

Jul 2000
Volume 17 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Seki A, Yoshinouchi M, Seki N, Kodama J, Miyagi Y and Kudo T: Detection of c-erbB-2 and FGF-3 (INT-2) gene amplification in epithelial ovarian cancer.. Int J Oncol 17: 103-109, 2000
APA
Seki, A., Yoshinouchi, M., Seki, N., Kodama, J., Miyagi, Y., & Kudo, T. (2000). Detection of c-erbB-2 and FGF-3 (INT-2) gene amplification in epithelial ovarian cancer.. International Journal of Oncology, 17, 103-109. https://doi.org/10.3892/ijo.17.1.103
MLA
Seki, A., Yoshinouchi, M., Seki, N., Kodama, J., Miyagi, Y., Kudo, T."Detection of c-erbB-2 and FGF-3 (INT-2) gene amplification in epithelial ovarian cancer.". International Journal of Oncology 17.1 (2000): 103-109.
Chicago
Seki, A., Yoshinouchi, M., Seki, N., Kodama, J., Miyagi, Y., Kudo, T."Detection of c-erbB-2 and FGF-3 (INT-2) gene amplification in epithelial ovarian cancer.". International Journal of Oncology 17, no. 1 (2000): 103-109. https://doi.org/10.3892/ijo.17.1.103