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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jul 2000 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jul 2000 Volume 17 Issue 1

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Article

Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.

  • Authors:
    • A Mariano
    • A Di Carlo
    • C Santonastaso
    • A Oliva
    • M D'Armiento
    • V Macchia

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Napoli, Italy.
  • Pages: 167-238
    |
    Published online on: July 1, 2000
       https://doi.org/10.3892/ijo.17.1.167
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Abstract

The prostate specific antigen (PSA) content, the neuroendocrine differentiation and the Lewis(y) and the expression of related carbohydrate antigens in pathological prostatic tissues were determined. These included 13 cancers and 11 benign hyperplasias. PSA is expressed strongly in hyperplastic and poorly in neoplastic tissues. The neuroendocrine differentiation detected by a monoclonal antibody directed against chromogranin A (CgA) is a frequent event in carcinomas and rare in hyperplastic prostate. The Lewis(y) and related carbohydrate antigens, evaluated by the reactivity of the tissues to two monoclonal antibodies MAbB3 and MAbB1, are expressed in a considerable percentage in malignant tissues of prostate and only occasionally in benign lesions. Our results suggest that immunoblotting with antibodies against CgA, B3 and B1 on the tissues, obtained after surgery, may be useful to obtain more information on the neoplastic transformation of human prostate. Furthermore, the expression of Lewis(y) and related carbohydrate antigens on the surface of prostate cancer suggest that, following a clinical trial, an immunotoxin combination of MAbB3 or MAbB1 and Pseudomonas exotoxin, may be used in the treatment of prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Mariano A, Di Carlo A, Santonastaso C, Oliva A, D'Armiento M and Macchia V: Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.. Int J Oncol 17: 167-238, 2000.
APA
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., & Macchia, V. (2000). Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.. International Journal of Oncology, 17, 167-238. https://doi.org/10.3892/ijo.17.1.167
MLA
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., Macchia, V."Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.". International Journal of Oncology 17.1 (2000): 167-238.
Chicago
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., Macchia, V."Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.". International Journal of Oncology 17, no. 1 (2000): 167-238. https://doi.org/10.3892/ijo.17.1.167
Copy and paste a formatted citation
x
Spandidos Publications style
Mariano A, Di Carlo A, Santonastaso C, Oliva A, D'Armiento M and Macchia V: Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.. Int J Oncol 17: 167-238, 2000.
APA
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., & Macchia, V. (2000). Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.. International Journal of Oncology, 17, 167-238. https://doi.org/10.3892/ijo.17.1.167
MLA
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., Macchia, V."Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.". International Journal of Oncology 17.1 (2000): 167-238.
Chicago
Mariano, A., Di Carlo, A., Santonastaso, C., Oliva, A., D'Armiento, M., Macchia, V."Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer.". International Journal of Oncology 17, no. 1 (2000): 167-238. https://doi.org/10.3892/ijo.17.1.167
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