Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.

  • Authors:
    • A Handa
    • T Tokunaga
    • T Tsuchida
    • Y H Lee
    • H Kijima
    • H Yamazaki
    • Y Ueyama
    • H Fukuda
    • M Nakamura
  • View Affiliations

  • Published online on: August 1, 2000     https://doi.org/10.3892/ijo.17.2.291
  • Pages: 291-296
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Abstract

Osteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 expression (n=24) showed a significantly increased vascularity (P<0.0014, Mann-Whitney U test). Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2 (P=0.016, Wilcoxon's test). These results suggest that NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression.

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Aug 2000
Volume 17 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Handa A, Tokunaga T, Tsuchida T, Lee Y, Kijima H, Yamazaki H, Ueyama Y, Fukuda H and Nakamura M: Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.. Int J Oncol 17: 291-296, 2000.
APA
Handa, A., Tokunaga, T., Tsuchida, T., Lee, Y., Kijima, H., Yamazaki, H. ... Nakamura, M. (2000). Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.. International Journal of Oncology, 17, 291-296. https://doi.org/10.3892/ijo.17.2.291
MLA
Handa, A., Tokunaga, T., Tsuchida, T., Lee, Y., Kijima, H., Yamazaki, H., Ueyama, Y., Fukuda, H., Nakamura, M."Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.". International Journal of Oncology 17.2 (2000): 291-296.
Chicago
Handa, A., Tokunaga, T., Tsuchida, T., Lee, Y., Kijima, H., Yamazaki, H., Ueyama, Y., Fukuda, H., Nakamura, M."Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.". International Journal of Oncology 17, no. 2 (2000): 291-296. https://doi.org/10.3892/ijo.17.2.291