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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Aug 2000 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 2000 Volume 17 Issue 2

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Article

Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.

  • Authors:
    • S Nishihara
    • T Hayashida
    • K Mitsuya
    • T C Schulz
    • M Ikeguchi
    • N Kaibara
    • M Oshimura

  • View Affiliations / Copyright

    Affiliations: Core Research for Evolutional Science and Technology (CREST) Program, Department of Molecular and Cell Genetics, School of Life Sciences, Tottori 683-8503, Japan.
  • Pages: 317-339
    |
    Published online on: August 1, 2000
       https://doi.org/10.3892/ijo.17.2.317
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Abstract

Disrupted imprinting is implicated in certain tumorigenesis. Since aberrant methylation has been described for a majority of microsatellite instability (MSI)-positive sporadic colorectal cancers, we have investigated alteration to the imprinting in 55 sporadic colorectal cancers with or without MSI. Loss of imprinting (LOI) of IGF2 and PEG1/MEST was observed in 42% and 35% of informative cancers, respectively. H19 expression was not detected in 24% of informative cancers. SNRPN and NDN retained monoallelic expression in all the cancers examined. These findings indicate no simultaneous disruption of the imprinted genes. LOI of IGF2 and PEG1/MEST was also observed in colorectal mucosa from almost all the patients with LOI in tumor tissue. Moreover, MSI-positive colorectal cancers exhibit LOI of IGF2 with a high frequency compared to MSI-negative cancers (P=0.013). These observations, consistent with a previous report, establish an association between LOI of IGF2 and MSI in colorectal cancers and provide insight into susceptibility of tumor development.

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Copy and paste a formatted citation
Spandidos Publications style
Nishihara S, Hayashida T, Mitsuya K, Schulz T, Ikeguchi M, Kaibara N and Oshimura M: Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.. Int J Oncol 17: 317-339, 2000.
APA
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., & Oshimura, M. (2000). Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.. International Journal of Oncology, 17, 317-339. https://doi.org/10.3892/ijo.17.2.317
MLA
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., Oshimura, M."Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.". International Journal of Oncology 17.2 (2000): 317-339.
Chicago
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., Oshimura, M."Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.". International Journal of Oncology 17, no. 2 (2000): 317-339. https://doi.org/10.3892/ijo.17.2.317
Copy and paste a formatted citation
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Spandidos Publications style
Nishihara S, Hayashida T, Mitsuya K, Schulz T, Ikeguchi M, Kaibara N and Oshimura M: Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.. Int J Oncol 17: 317-339, 2000.
APA
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., & Oshimura, M. (2000). Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.. International Journal of Oncology, 17, 317-339. https://doi.org/10.3892/ijo.17.2.317
MLA
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., Oshimura, M."Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.". International Journal of Oncology 17.2 (2000): 317-339.
Chicago
Nishihara, S., Hayashida, T., Mitsuya, K., Schulz, T., Ikeguchi, M., Kaibara, N., Oshimura, M."Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.". International Journal of Oncology 17, no. 2 (2000): 317-339. https://doi.org/10.3892/ijo.17.2.317
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