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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Aug 2000 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 2000 Volume 17 Issue 2

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Article

Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.

  • Authors:
    • H Iguchi
    • M Ono
    • K Matsushima
    • M Kuwano

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan.
  • Pages: 329-362
    |
    Published online on: August 1, 2000
       https://doi.org/10.3892/ijo.17.2.329
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Abstract

HARA-B cells were established from the bone lesion in nude mice formed after an intracardiac inoculation of the human lung cancer-derived cells (HARA), and production of IL-8 in HARA-B cells was decreased as compared to that in the parental HARA cells. This suggests a possible relationship between IL-8 production and bone metastasis. Thus, we examined the effect of IL-8 on bone metastasis using HARA-B cells transfected with experimental (IL-8-cDNA) and/or control plasmid in the experimental bone metastasis model in nude mice. Growth rates of both cells in vitro were similar. Control cells developed radiologically detectable bone metastases in 50% of nude mice tested, whereas experimental cells did not develop bone metastases. Osteoclastic bone resorption is an important step in the process of bone metastasis, and IL-8 possesses an inhibitory effect on osteoclastic bone resorption. These results suggest that IL-8 suppresses bone metastasis, which might be attributed to the inhibitory effect of IL-8 on osteoclastic bone resorption.

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Copy and paste a formatted citation
Spandidos Publications style
Iguchi H, Ono M, Matsushima K and Kuwano M: Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.. Int J Oncol 17: 329-362, 2000.
APA
Iguchi, H., Ono, M., Matsushima, K., & Kuwano, M. (2000). Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.. International Journal of Oncology, 17, 329-362. https://doi.org/10.3892/ijo.17.2.329
MLA
Iguchi, H., Ono, M., Matsushima, K., Kuwano, M."Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.". International Journal of Oncology 17.2 (2000): 329-362.
Chicago
Iguchi, H., Ono, M., Matsushima, K., Kuwano, M."Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.". International Journal of Oncology 17, no. 2 (2000): 329-362. https://doi.org/10.3892/ijo.17.2.329
Copy and paste a formatted citation
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Spandidos Publications style
Iguchi H, Ono M, Matsushima K and Kuwano M: Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.. Int J Oncol 17: 329-362, 2000.
APA
Iguchi, H., Ono, M., Matsushima, K., & Kuwano, M. (2000). Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.. International Journal of Oncology, 17, 329-362. https://doi.org/10.3892/ijo.17.2.329
MLA
Iguchi, H., Ono, M., Matsushima, K., Kuwano, M."Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.". International Journal of Oncology 17.2 (2000): 329-362.
Chicago
Iguchi, H., Ono, M., Matsushima, K., Kuwano, M."Overproduction of IL-8 results in suppression of bone metastasis by lung cancer cells in vivo.". International Journal of Oncology 17, no. 2 (2000): 329-362. https://doi.org/10.3892/ijo.17.2.329
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