Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.

  • Authors:
    • S Nagano
    • S Matsunaga
    • R Takae
    • N Morimoto
    • S Suzuki
    • H Yoshida
  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/ijo.17.3.461
  • Pages: 461-467
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Abstract

The temporal and spatial immunolocalization of TGF-betas and their receptors in the intervertebral disk of senescence-accelerated mouse (SAM) was examined to determine the biological roles played by TGF-betas and their receptors in the process of intervertebral disk degeneration. Ten male SAM and ICR mice aged 8, 24 or 50 weeks after birth were used for this experiment. Histological and immunohistochemical studies using specific antibodies for TGF-beta1, -beta2, -beta3, TbetaR-I, and TbetaR-II were performed. Intervertebral disks of SAM exhibited more degenerative changes than those of ICR mice. Expression of TGF-betas and TbetaRs in disk of SAM and ICR mice was observed at 8 weeks of age, and became weaker with aging. Our results suggest TGF-betas may play a role in the growth and maintenance of intervertebal disks.

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Sep 2000
Volume 17 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nagano S, Matsunaga S, Takae R, Morimoto N, Suzuki S and Yoshida H: Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.. Int J Oncol 17: 461-467, 2000
APA
Nagano, S., Matsunaga, S., Takae, R., Morimoto, N., Suzuki, S., & Yoshida, H. (2000). Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.. International Journal of Oncology, 17, 461-467. https://doi.org/10.3892/ijo.17.3.461
MLA
Nagano, S., Matsunaga, S., Takae, R., Morimoto, N., Suzuki, S., Yoshida, H."Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.". International Journal of Oncology 17.3 (2000): 461-467.
Chicago
Nagano, S., Matsunaga, S., Takae, R., Morimoto, N., Suzuki, S., Yoshida, H."Immunolocalization of transforming growth factor-betas and their receptors in the intervertebral disk of senescence-accelerated mouse.". International Journal of Oncology 17, no. 3 (2000): 461-467. https://doi.org/10.3892/ijo.17.3.461