Instability at dinucleotide and trinucleotide repeats in breast cancer.

  • Authors:
    • L Ottini
    • D Palli
    • M Falchetti
    • C D'Amico
    • C Noviello
    • C Saieva
    • A Russo
    • A M Corsi
    • G Masala
    • M Paglierani
    • V Vezzosi
    • S Bianchi
    • R Mariani-Costantini
  • View Affiliations

  • Published online on: October 1, 2000     https://doi.org/10.3892/ijo.17.4.819
  • Pages: 819-845
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Abstract

We analyzed 7 mono-, 6 di- and 2 trinucleotide repeat loci in a well characterized series of 69 breast cancer cases, treated in the period 1985-1986 and followed for 12 years. Tumor-associated allele contractions or expansions were observed only at di- and trinucleotide repeats, and were detected in 14/69 cases (20%), of which 7 (10%) showed instability at 2 or more loci (10%). No alterations were detected at mononucleotide repeats known to be unstable in gastrointestinal tumors with the microsatellite mutator phenotype. Disease-free survival at 5 years, overall survival at 12 years of follow-up, tumor stage, estrogen/progesteron receptor status, and expression of the Ki-67 proliferation marker were independent of microsatellite status.

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Oct 2000
Volume 17 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ottini L, Palli D, Falchetti M, D'Amico C, Noviello C, Saieva C, Russo A, Corsi A, Masala G, Paglierani M, Paglierani M, et al: Instability at dinucleotide and trinucleotide repeats in breast cancer.. Int J Oncol 17: 819-845, 2000
APA
Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Noviello, C., Saieva, C. ... Mariani-Costantini, R. (2000). Instability at dinucleotide and trinucleotide repeats in breast cancer.. International Journal of Oncology, 17, 819-845. https://doi.org/10.3892/ijo.17.4.819
MLA
Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Noviello, C., Saieva, C., Russo, A., Corsi, A., Masala, G., Paglierani, M., Vezzosi, V., Bianchi, S., Mariani-Costantini, R."Instability at dinucleotide and trinucleotide repeats in breast cancer.". International Journal of Oncology 17.4 (2000): 819-845.
Chicago
Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Noviello, C., Saieva, C., Russo, A., Corsi, A., Masala, G., Paglierani, M., Vezzosi, V., Bianchi, S., Mariani-Costantini, R."Instability at dinucleotide and trinucleotide repeats in breast cancer.". International Journal of Oncology 17, no. 4 (2000): 819-845. https://doi.org/10.3892/ijo.17.4.819