PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells.

  • Authors:
    • A Elnemr
    • T Ohta
    • K Iwata
    • I Ninomia
    • S Fushida
    • G Nishimura
    • H Kitagawa
    • M Kayahara
    • M Yamamoto
    • T Terada
    • K Miwa
  • View Affiliations

  • Published online on: December 1, 2000     https://doi.org/10.3892/ijo.17.6.1157
  • Pages: 1157-1221
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Abstract

The aim of this study was to examine whether a specific PPARgamma ligand can inhibit the growth of human pancreatic cancer cells through induction of terminal differentiation. PPARgamma was expressed in five human pancreatic cancer cell lines: Capan-1, AsPC-1, BxPC-3, PANC-1, and MIA PaCa-2. Treatment of these cells with a specific PPARgamma ligand, thiazolidinedione (TZD), resulted in inhibition of both cellular and clonogenic growth, and G1 cell cycle arrest. Finally, thiazolidinedione treatment resulted in induction of p21WAF-1 and increased expression of differentiation markers. These results suggest that thiazolidinedione treatment inhibits growth and induces cellular differentiation in pancreatic cancer cells and thereby reduces their development in favor of differentiated and stable cell phenotype.

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Dec 2000
Volume 17 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Elnemr A, Ohta T, Iwata K, Ninomia I, Fushida S, Nishimura G, Kitagawa H, Kayahara M, Yamamoto M, Terada T, Terada T, et al: PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells.. Int J Oncol 17: 1157-1221, 2000.
APA
Elnemr, A., Ohta, T., Iwata, K., Ninomia, I., Fushida, S., Nishimura, G. ... Miwa, K. (2000). PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells.. International Journal of Oncology, 17, 1157-1221. https://doi.org/10.3892/ijo.17.6.1157
MLA
Elnemr, A., Ohta, T., Iwata, K., Ninomia, I., Fushida, S., Nishimura, G., Kitagawa, H., Kayahara, M., Yamamoto, M., Terada, T., Miwa, K."PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells.". International Journal of Oncology 17.6 (2000): 1157-1221.
Chicago
Elnemr, A., Ohta, T., Iwata, K., Ninomia, I., Fushida, S., Nishimura, G., Kitagawa, H., Kayahara, M., Yamamoto, M., Terada, T., Miwa, K."PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells.". International Journal of Oncology 17, no. 6 (2000): 1157-1221. https://doi.org/10.3892/ijo.17.6.1157