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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Dec 2000 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 2000 Volume 17 Issue 6

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Article

p21WAF1/CIP1 protein expression in primary ovarian cancer.

  • Authors:
    • G Ferrandina
    • A Stoler
    • A Fagotti
    • F Fanfani
    • R Sacco
    • A De Pasqua
    • S Mancuso
    • G Scambia

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Catholic University, Rome, Italy.
  • Pages: 1231-1236
    |
    Published online on: December 1, 2000
       https://doi.org/10.3892/ijo.17.6.1231
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Abstract

p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, able to prevent the CDK2/cyclin E induced retinoblastoma protein (pRB) phosphorylation, thus inhibiting cell cycle progression at G1 phase. p21WAF1/CIP1 protein levels were examined in a series of 102 ovarian tissue samples including normal ovary, primary ovarian tumors, omental metastasis, recurrent disease and residual tumor after chemotherapy exposure, by Western blot analysis. The association of p21WAF1/CIP1 status with clinicopathological parameters and clinical outcome was also investigated. p21WAF1/CIP1 protein was detectable in 76 out of 102 (74%) ovarian tissue samples. We observed a significant trend of p21 levels to gradually increase from normal ovarian tissues (median 0 a.u.) through primary ovarian cancers (median 0.19 a.u.), omental metastases (median 0.33 a.u.) and recurrence of disease (median 0.44 a.u.) (p=0.015). In the group of stage III-IV ovarian cancer patients, p21-positive cases showed a more favourable prognosis with respect to p21-negative cases: the 3-year time to progression (TTP) rate was 58% for p21-positive compared with 33% of p21-negative cases (p=0.036). In conclusion, p21WAF1/CIP1 expression levels seem to be correlated with tumor status at the time of diagnosis and can predict TTP in a selected group of patients.

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Copy and paste a formatted citation
Spandidos Publications style
Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S and Scambia G: p21WAF1/CIP1 protein expression in primary ovarian cancer.. Int J Oncol 17: 1231-1236, 2000.
APA
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A. ... Scambia, G. (2000). p21WAF1/CIP1 protein expression in primary ovarian cancer.. International Journal of Oncology, 17, 1231-1236. https://doi.org/10.3892/ijo.17.6.1231
MLA
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A., Mancuso, S., Scambia, G."p21WAF1/CIP1 protein expression in primary ovarian cancer.". International Journal of Oncology 17.6 (2000): 1231-1236.
Chicago
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A., Mancuso, S., Scambia, G."p21WAF1/CIP1 protein expression in primary ovarian cancer.". International Journal of Oncology 17, no. 6 (2000): 1231-1236. https://doi.org/10.3892/ijo.17.6.1231
Copy and paste a formatted citation
x
Spandidos Publications style
Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S and Scambia G: p21WAF1/CIP1 protein expression in primary ovarian cancer.. Int J Oncol 17: 1231-1236, 2000.
APA
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A. ... Scambia, G. (2000). p21WAF1/CIP1 protein expression in primary ovarian cancer.. International Journal of Oncology, 17, 1231-1236. https://doi.org/10.3892/ijo.17.6.1231
MLA
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A., Mancuso, S., Scambia, G."p21WAF1/CIP1 protein expression in primary ovarian cancer.". International Journal of Oncology 17.6 (2000): 1231-1236.
Chicago
Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., De Pasqua, A., Mancuso, S., Scambia, G."p21WAF1/CIP1 protein expression in primary ovarian cancer.". International Journal of Oncology 17, no. 6 (2000): 1231-1236. https://doi.org/10.3892/ijo.17.6.1231
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